Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤여준 | - |
dc.date.accessioned | 2019-03-27T16:30:13Z | - |
dc.date.available | 2019-03-27T16:30:13Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1367-5435 | - |
dc.identifier.other | OAK-24460 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/249551 | - |
dc.description.abstract | Macrolides, especially 14-membered macrolides, are a valuable group of antibiotics that originate from various microorganisms. In addition to their antibacterial activity, newly discovered 14-membered macrolides exhibit other therapeutic potentials, such as anti-proliferative and anti-protistal activities. Combinatorial biosynthetic approaches will allow us to create structurally diversified macrolide analogs, which are especially important during the emerging post-antibiotic era. This review focuses on recent advances in the discovery of new 14-membered macrolides (also including macrolactones) from microorganisms and the current status of combinatorial biosynthetic approaches, including polyketide synthase (PKS) and post-PKS tailoring pathways, and metabolic engineering for improved production together with heterologous production of 14-membered macrolides. © 2018, Society for Industrial Microbiology and Biotechnology. | - |
dc.language | English | - |
dc.publisher | Springer Verlag | - |
dc.subject | 14-Membered macrolide | - |
dc.subject | Combinatorial biosynthesis | - |
dc.subject | Polyketide synthase | - |
dc.subject | Post-polyketide synthase tailoring | - |
dc.title | Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones | - |
dc.type | Article | - |
dc.relation.issue | 43528.0 | - |
dc.relation.volume | 46 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 445 | - |
dc.relation.lastpage | 458 | - |
dc.relation.journaltitle | Journal of Industrial Microbiology and Biotechnology | - |
dc.identifier.doi | 10.1007/s10295-018-2095-4 | - |
dc.identifier.wosid | WOS:000460642800017 | - |
dc.identifier.scopusid | 2-s2.0-85056298131 | - |
dc.author.google | Park J.W. | - |
dc.author.google | Yoon Y.J. | - |
dc.contributor.scopusid | 윤여준(7402126465) | - |
dc.date.modifydate | 20210915114818 | - |