View : 21 Download: 0
Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones
- Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones
- Park J.W.; Yoon Y.J.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Journal of Industrial Microbiology and Biotechnology
- Journal of Industrial Microbiology and Biotechnology vol. 46, no. 43528.0, pp. 445 - 458
- 14-Membered macrolide; Combinatorial biosynthesis; Polyketide synthase; Post-polyketide synthase tailoring
- Springer Verlag
- SCI; SCIE; SCOPUS
- Document Type
- Macrolides, especially 14-membered macrolides, are a valuable group of antibiotics that originate from various microorganisms. In addition to their antibacterial activity, newly discovered 14-membered macrolides exhibit other therapeutic potentials, such as anti-proliferative and anti-protistal activities. Combinatorial biosynthetic approaches will allow us to create structurally diversified macrolide analogs, which are especially important during the emerging post-antibiotic era. This review focuses on recent advances in the discovery of new 14-membered macrolides (also including macrolactones) from microorganisms and the current status of combinatorial biosynthetic approaches, including polyketide synthase (PKS) and post-PKS tailoring pathways, and metabolic engineering for improved production together with heterologous production of 14-membered macrolides. © 2018, Society for Industrial Microbiology and Biotechnology.
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.