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Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones

Title
Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones
Authors
Park J.W.Yoon Y.J.
Ewha Authors
윤여준
SCOPUS Author ID
윤여준scopus
Issue Date
2019
Journal Title
Journal of Industrial Microbiology and Biotechnology
ISSN
1367-5435JCR Link
Citation
Journal of Industrial Microbiology and Biotechnology vol. 46, no. 43528.0, pp. 445 - 458
Keywords
14-Membered macrolideCombinatorial biosynthesisPolyketide synthasePost-polyketide synthase tailoring
Publisher
Springer Verlag
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Macrolides, especially 14-membered macrolides, are a valuable group of antibiotics that originate from various microorganisms. In addition to their antibacterial activity, newly discovered 14-membered macrolides exhibit other therapeutic potentials, such as anti-proliferative and anti-protistal activities. Combinatorial biosynthetic approaches will allow us to create structurally diversified macrolide analogs, which are especially important during the emerging post-antibiotic era. This review focuses on recent advances in the discovery of new 14-membered macrolides (also including macrolactones) from microorganisms and the current status of combinatorial biosynthetic approaches, including polyketide synthase (PKS) and post-PKS tailoring pathways, and metabolic engineering for improved production together with heterologous production of 14-membered macrolides. © 2018, Society for Industrial Microbiology and Biotechnology.
DOI
10.1007/s10295-018-2095-4
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자연과학대학 > 화학·나노과학전공 > Journal papers
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