Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박준범 | * |
dc.date.accessioned | 2019-03-27T16:30:07Z | - |
dc.date.available | 2019-03-27T16:30:07Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 0513-5796 | * |
dc.identifier.issn | 1976-2437 | * |
dc.identifier.other | OAK-24495 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/249521 | - |
dc.description.abstract | Purpose: Label adherence for non-vitamin K antagonist oral anticoagulants (NOACs) has not been well evaluated in Asian patients with non-valvular atrial fibrillation (AF). The present study aimed to assess label adherence for NOACs in a Korean AF population and to determine risk factors of off-label prescriptions of NOACs. Materials and Methods: In this COmparison study of Drugs for symptom control and complication prEvention of AF (CODE-AF) registry, patients with AF who were prescribed NOACs between June 2016 and May 2017 were included. Four NOAC doses were categorized as on- or off-label use according to Korea Food and Drug Regulations. Results: We evaluated 3080 AF patients treated with NOACs (dabigatran 27.2%, rivaroxaban 23.9%, apixaban 36.9%, and edoxaban 12.0%). The mean age was 70.5 +/- 9.2 years; 56.0% were men; and the mean CHA(2)DS(2)-VASc score was 3.3 +/- 1.4. Only one-third of the patients (32.7%) was prescribed a standard dose of NOAC. More than one-third of the study population (n=1122, 36.4%) was prescribed an off-label reduced dose of NOAC. Compared to those with an on-label standard dosing, patients with an off-label reduced dose of NOAC were older (>= 75 years), women, and had a lower body weight (<= 60 kg), renal dysfunction (creatinine clearance <= 50 mL/min), previous stroke, previous bleeding, hypertension, concomitant dronedarone use, and anti-platelet use. Conclusion: In real-world practice, more than one-third of patients with NOAC prescriptions received an off-label reduced dose, which could result in an increased risk of stroke. Considering the high risk of stroke in these patients, on-label use of NOAC is recommended. | * |
dc.language | English | * |
dc.publisher | YONSEI UNIV COLL MEDICINE | * |
dc.subject | Atrial fibrillation | * |
dc.subject | non-vitamin K antagonist oral anticoagulant | * |
dc.subject | drug labeling | * |
dc.subject | dose | * |
dc.title | Label Adherence for Non-Vitamin K Antagonist Oral Anticoagulants in a Prospective Cohort of Asian Patients with Atrial Fibrillation | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 60 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 277 | * |
dc.relation.lastpage | 284 | * |
dc.relation.journaltitle | YONSEI MEDICAL JOURNAL | * |
dc.identifier.doi | 10.3349/ymj.2019.60.3.277 | * |
dc.identifier.wosid | WOS:000459544000005 | * |
dc.identifier.scopusid | 2-s2.0-85062076240 | * |
dc.author.google | Lee, So-Ryoung | * |
dc.author.google | Lee, Young Soo | * |
dc.author.google | Park, Ji-Suck | * |
dc.author.google | Cha, Myung-Jin | * |
dc.author.google | Kim, Tae-Hoon | * |
dc.author.google | Park, Junbeom | * |
dc.author.google | Park, Jin-Kyu | * |
dc.author.google | Lee, Jung-Myung | * |
dc.author.google | Kang, Ki-Woon | * |
dc.author.google | Shim, Jaemin | * |
dc.author.google | Uhm, Jae-Sun | * |
dc.author.google | Kim, Jun | * |
dc.author.google | Kim, Changsoo | * |
dc.author.google | Kim, Jin-Bae | * |
dc.author.google | Park, Hyung Wook | * |
dc.author.google | Joung, Boyoung | * |
dc.author.google | Choi, Eue-Keun | * |
dc.contributor.scopusid | 박준범(55131469900) | * |
dc.date.modifydate | 20240222143915 | * |