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Is tumor bed boost necessary in patients who achieved ypCR following neoadjuvant chemotherapy and breast conserving therapy? (KROG 12-05 and 16-16)

Title
Is tumor bed boost necessary in patients who achieved ypCR following neoadjuvant chemotherapy and breast conserving therapy? (KROG 12-05 and 16-16)
Authors
Cho, Won KyungPark, WonChoi, Doo HoKim, Yong BaeSu, Chang-OkShin, Kyung HwanChie, Eui KyuKim, Jin HoAhn, Seung DoKim, Su SsanKim, KyuboKim, Jin HeeAhn, Sung JaLee, Sun YoungLee, JeongshimKim, Sang-WonKwon, JeannyAhn, Ki JungShin, Hyun SooLee, Hyung SikLee, Nam Kwon
Ewha Authors
김규보
SCOPUS Author ID
김규보scopus
Issue Date
2019
Journal Title
BREAST
ISSN
0960-9776JCR Link

1532-3080JCR Link
Citation
BREAST vol. 45, pp. 43 - 47
Keywords
Breast cancerNeoadjuvant chemotherapyTumor bed boostRadiotherapy
Publisher
CHURCHILL LIVINGSTONE
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Purpose: This multi-institutional study intended to investigate the effect of tumor bed boost in patients who achieved pathologic complete response (ypCR) following neoadjuvant chemotherapy (NAC) and breast-conserving therapy (BCT). Materials and methods: We identified 180 patients who initially had lymph node (LN) metastasis and achieved ypCR (ypT0/isN0) following NAC and BCT from the 13 institutions of the Korean Radiation Oncology Group (KROG) 16-16 and KROG 12-05. The effect of tumor bed boost on loco-regional control (LRC), disease-free survival (DFS), and overall survival (OS) rates was analyzed. Results: In all patients, five-year LRC, DFS and OS rates were 97.5%, 95.4%, and 99.4%, respectively. Tumor bed boost was performed in 158 (87.8%) patients. Advanced N-stage (cN2-3, p = 0.036), close resection margin (p < 0.001), and sentinel lymph node biopsy (p = 0.040) were unfavorable factors for DFS. Tumor bed boost was not a significant factor for LRC, DFS, and OS. Conclusions: This study suggests the benefit of tumor bed boost might be minimal in ypCR patients following NAC and BCT. Larger prospective studies are needed to address this issue. (C) 2019 Published by Elsevier Ltd.
DOI
10.1016/j.breast.2019.02.010
Appears in Collections:
의과대학 > 의학과 > Journal papers
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