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Is tumor bed boost necessary in patients who achieved ypCR following neoadjuvant chemotherapy and breast conserving therapy? (KROG 12-05 and 16-16)
- Is tumor bed boost necessary in patients who achieved ypCR following neoadjuvant chemotherapy and breast conserving therapy? (KROG 12-05 and 16-16)
- Cho, Won Kyung; Park, Won; Choi, Doo Ho; Kim, Yong Bae; Su, Chang-Ok; Shin, Kyung Hwan; Chie, Eui Kyu; Kim, Jin Ho; Ahn, Seung Do; Kim, Su Ssan; Kim, Kyubo; Kim, Jin Hee; Ahn, Sung Ja; Lee, Sun Young; Lee, Jeongshim; Kim, Sang-Won; Kwon, Jeanny; Ahn, Ki Jung; Shin, Hyun Soo; Lee, Hyung Sik; Lee, Nam Kwon
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- BREAST vol. 45, pp. 43 - 47
- Breast cancer; Neoadjuvant chemotherapy; Tumor bed boost; Radiotherapy
- CHURCHILL LIVINGSTONE
- SCIE; SCOPUS
- Document Type
- Purpose: This multi-institutional study intended to investigate the effect of tumor bed boost in patients who achieved pathologic complete response (ypCR) following neoadjuvant chemotherapy (NAC) and breast-conserving therapy (BCT). Materials and methods: We identified 180 patients who initially had lymph node (LN) metastasis and achieved ypCR (ypT0/isN0) following NAC and BCT from the 13 institutions of the Korean Radiation Oncology Group (KROG) 16-16 and KROG 12-05. The effect of tumor bed boost on loco-regional control (LRC), disease-free survival (DFS), and overall survival (OS) rates was analyzed. Results: In all patients, five-year LRC, DFS and OS rates were 97.5%, 95.4%, and 99.4%, respectively. Tumor bed boost was performed in 158 (87.8%) patients. Advanced N-stage (cN2-3, p = 0.036), close resection margin (p < 0.001), and sentinel lymph node biopsy (p = 0.040) were unfavorable factors for DFS. Tumor bed boost was not a significant factor for LRC, DFS, and OS. Conclusions: This study suggests the benefit of tumor bed boost might be minimal in ypCR patients following NAC and BCT. Larger prospective studies are needed to address this issue. (C) 2019 Published by Elsevier Ltd.
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