Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박상희 | * |
dc.contributor.author | 안영호 | * |
dc.date.accessioned | 2019-02-26T16:30:04Z | - |
dc.date.available | 2019-02-26T16:30:04Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1226-3613 | * |
dc.identifier.issn | 2092-6413 | * |
dc.identifier.other | OAK-24414 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/249385 | - |
dc.description.abstract | Three miR-34 family members (miR-34a, miR-34b, and miR-34c) are clustered on two different chromosomal loci, Mir34a and Mir34b/c. These miRNAs have identical seed sequences, which are predicted to target the same set of genes. However, miR-34a and miR-34c have different sets of negatively correlated genes in lung adenocarcinoma data from The Cancer Genome Atlas. Therefore, we hypothesized that the individual miR-34 family members, which are tumor suppressive miRNAs, would have varying effects on lung tumorigenesis. To show this, we overexpressed each miR-34 cluster in murine lung cancer cells. MiR-34b/c enhanced cancer cell attachment and suppressed cell growth and invasion compared with miR-34a. In a syngeneic mouse model, both miR-34a and miR-34b/c blocked lung metastasis. However, miR-34b/c suppressed tumor growth more than miR-34a. MiR-34b/c also decreased the expression of mesenchymal markers (Cdh2 and Fn1) and increased the expression of epithelial markers (Cldn3, Dsp, and miR-200) to a greater degree than miR-34a. These results imply that miR-34b and miR-34c inhibit epithelial-to-mesenchymal transition. Furthermore, knockout of all three miR-34 members promoted mutant Kras-driven lung tumor progression in mice. Similarly, lung adenocarcinoma patients with higher miR-34a/b/c levels had better survival rates than did those with lower levels. In summary, we suggest that miR-34b and miR-34c are more effective tumor suppressors than miR-34a. | * |
dc.language | English | * |
dc.publisher | NATURE PUBLISHING GROUP | * |
dc.title | MiR-34a and miR-34b/c have distinct effects on the suppression of lung adenocarcinomas | * |
dc.type | Article | * |
dc.relation.volume | 51 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.journaltitle | EXPERIMENTAL AND MOLECULAR MEDICINE | * |
dc.identifier.doi | 10.1038/s12276-018-0203-1 | * |
dc.identifier.wosid | WOS:000460463400001 | * |
dc.identifier.scopusid | 2-s2.0-85060937515 | * |
dc.author.google | Kim, Jeong Seon | * |
dc.author.google | Kim, Eun Ju | * |
dc.author.google | Lee, Sieun | * |
dc.author.google | Tan, Xiaochao | * |
dc.author.google | Liu, Xin | * |
dc.author.google | Park, Sanghui | * |
dc.author.google | Kang, Keunsoo | * |
dc.author.google | Yoon, Jung-Sook | * |
dc.author.google | Ko, Yoon Ho | * |
dc.author.google | Kurie, Jonathan M. | * |
dc.author.google | Ahn, Young-Ho | * |
dc.contributor.scopusid | 박상희(12041890800) | * |
dc.contributor.scopusid | 안영호(7202402440) | * |
dc.date.modifydate | 20240222132209 | * |