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dc.contributor.advisor김관묵-
dc.contributor.authorChen Qian-
dc.creatorChen Qian-
dc.date.accessioned2019-02-18T16:32:18Z-
dc.date.available2019-02-18T16:32:18Z-
dc.date.issued2019-
dc.identifier.otherOAK-000000153859-
dc.identifier.urihttp://dcollection.ewha.ac.kr/common/orgView/000000153859en_US
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/249080-
dc.description.abstractChirality of molecule was determined by its physical and chemical property of molecules which is due to symmetry elements. As we know, the chiral amino acid has an asymmetric carbon atom which processed four different substituents at center carbon atom which induce the chirality of molecules.1 The two different chiral molecules which have the same molecular weight but not superimposable each other on their mirror images. Such molecules can be defined as enantiomers. Enantiomers have identical chemical and physical properties such as boiling point, density and polarity in an achiral environment. Enantiomers rotate the direction of plane polarized light to equal, but opposite angles and interact with other chiral molecules differently. Chirality almost generated by a carbon atom with having four different substitution group of molecules. Meanwhile, other atoms also possess a stereogenic center such as phosphorus-nitrogen, and sulfur. Chirality fragments play as an essential fundament role in biological systems such as peptides, amino acids and sugars. In the late 1850, Pasteur, a French chemist who was first discovered the performance of stereochemistry with racemic isomers of ammonium tartrate induced by Penicillium glaucum.2 Over the past decades development of chirality chemistry, it is worthwhile mentioning that chiral compounds become a class of important instrument to the pharmaceutical industry, food additives and pesticides.3 Optical pure compounds have been extended to form most of the proteins, enzymes, and alkaloids. The nature of a living system is sensitive to chiral molecules and induce different responses during the process of interact with the enantiomer.;널리 알려진 것처럼 아미노산은 약품합성 및 카이랄성 리간드설계과정에서 중요한 역할을 하고 있습니다. 해마다 카이랄성 약품의 증가에 따라 아미노산의 수요도 늘어집니다. 그러므로 저희가 한 카이랄성 분할제를 설계했습니다. 메인 과제방향은 UryINH수식한 소분자분할제를 합성하는 것입니다. 이 전의 binol시스템에 비하여 분자량이 작고 구조를 쉽게 수식하며 카이랄성 중심이 아미노산에 가깝다는 장점이 있습니다. 저희가 이 분할제를 이용하여 아미노산수용액에서 D-아미노산을 분할하였습니다. 분할효율은 무려 12:1에 달합니다. 이 밖에는 회수하기 편하고 재활용할 수 있는 장점도 있습니다.-
dc.description.tableofcontentsCHAPTER I 1 1. General Introduction 1 1-1. The definition of Chirality 1 1-2. The example of pharmaceutical derived from amino acids 3 1-3. Asymmetric synthesis 4 1-4. Enzymatic catalysis approach 8 1-5. Enantiomer liquid-liquid extraction application 11 2. Research objectives 16 3. References 17 CHAPTER Ⅱ 22 A. Enantioselective extractor based on BINOL derivative 22 1. Introduction 22 2. Result and discussion 23 3. Experimental 28 4. Reference 31 B. Enantioselective Liquid-Liquid Extraction of Underivatized Amino Acids by Simple Derivative of Aniline-Aldehyde 32 1. Introduction 32 2. Results and discussion 34 3. Experimental section 41 4. Conclusion 45 5. Reference 46 CHAPTER Ⅲ 48 A. Conversion of underivatized amino acids via uryl pendant binol ketone 48 1. Introduction 48 2. Result and discussion 49 3. Experimental 50 4. Reference 52 CHAPTER Ⅳ 53 A. Chirality sensing amino acids via stereodynamic Zn-complex self-assembly 53 1. Introduction 53 2. Results and discussion 55 3. Conclusion 69 4. Experimental 70 5. Reference 73 APPENDIXES FOR CHAPTER Ⅱ-Ⅳ 75-
dc.formatapplication/pdf-
dc.format.extent9376459 bytes-
dc.languageeng-
dc.publisher이화여자대학교 대학원-
dc.subject.ddc500-
dc.titleEnantioselective Liquid−Liquid Extraction of Underivatized amino acids with Uryl-pendant Extractant-
dc.typeDoctoral Thesis-
dc.format.pageviii, 160 p.-
dc.identifier.thesisdegreeDoctor-
dc.identifier.major대학원 화학·나노과학과-
dc.date.awarded2019. 2-
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