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Small Molecule Modulators of the Circadian Molecular Clock With Implications for Neuropsychiatric Diseases

Title
Small Molecule Modulators of the Circadian Molecular Clock With Implications for Neuropsychiatric Diseases
Authors
Cha, Hyo KyeongChung, SooyoungLim, Hye YoungJung, Jong-WhaSon, Gi Hoon
Ewha Authors
정수영
SCOPUS Author ID
정수영scopus
Issue Date
2019
Journal Title
FRONTIERS IN MOLECULAR NEUROSCIENCE
ISSN
1662-5099JCR Link
Citation
FRONTIERS IN MOLECULAR NEUROSCIENCE vol. 11
Keywords
circadian rhythmcircadian clockcryptochromeREV-ERBRORsmall moleculecircadian rhythm-related disease
Publisher
FRONTIERS MEDIA SA
Indexed
SCIE; SCOPUS WOS
Document Type
Review
Abstract
Circadian rhythms regulate many biological processes and play fundamental roles in behavior, physiology, and metabolism. Such periodicity is critical for homeostasis because disruption or misalignment of the intrinsic rhythms is associated with the onset and progression of various human diseases and often directly leads to pathological states. Since the first identification of mammalian circadian clock genes, numerous genetic and biochemical studies have revealed the molecular basis of these cell-autonomous and self-sustainable rhythms. Specifically, these rhythms are generated by two interlocking transcription/translation feedback loops of clock proteins. As our understanding of these underlying mechanisms and their functional outputs has expanded, strategies have emerged to pharmacologically control the circadian molecular clock. Small molecules that target the molecular clock may present novel therapeutic strategies to treat chronic circadian rhythm-related diseases. These pharmaceutical approaches may include the development of new drugs to treat circadian clock-related disorders or combinational use with existing therapeutic strategies to improve efficacy via intrinsic clock-dependent mechanisms. Importantly, circadian rhythm disruptions correlate with, and often precede, many symptoms of various neuropsychiatric disorders such as sleep disorders, affective disorders, addiction-related disorders, and neurodegeneration. In this mini-review, we focus on recent discoveries of small molecules that pharmacologically modulate the core components of the circadian clock and their potential as preventive and/or therapeutic strategies for circadian clock-related neuropsychiatric diseases.
DOI
10.3389/fnmol.2018.00496
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스크랜튼대학 > 융합학부 > Journal papers
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