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Fabrication and characterization of 3D-printed elastic auricular scaffolds: A pilot study

Title
Fabrication and characterization of 3D-printed elastic auricular scaffolds: A pilot study
Authors
Kim H.Y.Jung S.Y.Lee S.J.Lee H.J.Truong M.-D.Kim H.S.
Ewha Authors
김한수
SCOPUS Author ID
김한수scopus
Issue Date
2019
Journal Title
Laryngoscope
ISSN
0023-852XJCR Link
Citation
Laryngoscope vol. 129, no. 2, pp. 351 - 357
Keywords
3D printingauricle reconstructionpolyurethaneporous scaffold
Publisher
John Wiley and Sons Inc.
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Objective: Aesthetic reconstruction of the external ear is challenging due to the complex anatomical shape of the auricle. Recently, artificial scaffolds such as Medpor (Stryker, Kalamasoo, MI, USA) have become widely used in ear reconstruction. However, the Medpor scaffold is stiffer than the natural ear, which may lead to discomfort, and moreover has uniform design for every patient. In this study, we investigated whether three-dimensional (3D)-printed artificial polyurethane (PU) scaffolds are suitable for auricular reconstruction. Methods: PU scaffolds were fabricated using 3D printing according to a design derived from a digital imaging and communications in medicine (DICOM) image of the human auricle. The microstructure of the scaffolds was observed using scanning electron microscopy, and the porosity was examined. Cell proliferation on the scaffolds was assessed in vitro using tonsil-derived mesenchymal stem cells to evaluate the biocompatibility of the scaffolds. The scaffolds were implanted in C57BL/6 mice, and histological analysis was performed. Results: The structural study revealed that the 3D-printed porous PU scaffolds have rectangular microstructure with regular pitch and line, as well as high porosity (56.46% ± 10.22%) with a pore diameter of 200 µm. The mechanical properties of the 3D-printed PU scaffolds were similar to those of the human auricle cartilage. Cell proliferation on the PU scaffolds was greater than that on Medpor scaffolds. Histological evaluation demonstrated that the porous parts of the PU scaffolds became filled with collagen and vascular tissue. Conclusion: Elastic, porous PU scaffolds can be obtained using 3D printing, have biomechanical properties similar to those of the natural ear, and are suitable for use in auricular reconstruction. Level of Evidence: NA Laryngoscope, 129:351–357, 2019. © 2018 The American Laryngological, Rhinological and Otological Society, Inc.
DOI
10.1002/lary.27344
Appears in Collections:
의과대학 > 의학과 > Journal papers
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