Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 손세정 | - |
dc.date.accessioned | 2019-02-15T16:30:05Z | - |
dc.date.available | 2019-02-15T16:30:05Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.other | OAK-24337 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/248373 | - |
dc.description.abstract | Background and Objectives: We investigated the status of infliximab use in intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) patients and the incidence of coronary artery aneurysms (CAAs) according to treatment regimens. Methods: Between March 2010 and February 2017, 16 hospitals participated in this study. A total of 102 (32.3±19.9 months, 72 males) who received infliximab at any time after first IVIG treatment failure were enrolled. Data were retrospectively collected using a questionnaire. Results: Subjects were divided into two groups according to the timing of infliximab administration. Early treatment (group 1) had shorter fever duration (10.5±4.4 days) until infliximab infusion than that in late treatment (group 2) (16.4±4.5 days; p<0.001). We investigated the response rate to infliximab and the incidence of significant CAA (z-score >5). Overall response rate to infliximab was 89/102 (87.3%) and the incidence of significant CAA was lower in group 1 than in group 2 (1/42 [2.4%] vs. 17/60 [28.3%], p<0.001). Conclusions: This study suggests that the early administration of infliximab may reduce the incidence of significant CAA in patients with IVIG-resistant KD. However, further prospective randomized studies with larger sample sizes are required. Copyright © 2019. The Korean Society of Cardiology | - |
dc.language | English | - |
dc.publisher | Korean Society of Circulation | - |
dc.subject | Coronary artery | - |
dc.subject | Infliximab | - |
dc.subject | Intravenous immunoglobulins | - |
dc.subject | Kawasaki disease | - |
dc.title | Infliximab treatment for intravenous immunoglobulin-resistant kawasaki disease: A multicenter study in Korea | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 49 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 183 | - |
dc.relation.lastpage | 191 | - |
dc.relation.journaltitle | Korean Circulation Journal | - |
dc.identifier.doi | 10.4070/kcj.2018.0214 | - |
dc.identifier.wosid | WOS:000457119700008 | - |
dc.identifier.scopusid | 2-s2.0-85061045806 | - |
dc.author.google | Hur G. | - |
dc.author.google | Seob Song M. | - |
dc.author.google | Sohn S. | - |
dc.author.google | Doo Lee H. | - |
dc.author.google | Beom Kim G. | - |
dc.author.google | Jin Cho H. | - |
dc.author.google | Lim Yoon K. | - |
dc.author.google | Uhng Joo C. | - |
dc.author.google | Chul Hyun M. | - |
dc.author.google | Ho Kim C. | - |
dc.contributor.scopusid | 손세정(56577409300) | - |
dc.date.modifydate | 20200903081003 | - |