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The Impact of Cholecystectomy on the Gut Microbiota: A Case-Control Study

Title
The Impact of Cholecystectomy on the Gut Microbiota: A Case-Control Study
Authors
Yoon, Won JaeKim, Han-NaPark, EunkyoRyu, SeunghoChang, YoosooShin, HocheolKim, Hyung-LaeYi, Sun Young
Ewha Authors
김형래이선영윤원재
SCOPUS Author ID
김형래scopus; 이선영scopus
Issue Date
2019
Journal Title
JOURNAL OF CLINICAL MEDICINE
ISSN
2077-0383JCR Link
Citation
JOURNAL OF CLINICAL MEDICINE vol. 8, no. 1
Keywords
cholecystectomymicrobiotagastrointestinal microbiome16S rRNA
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Cholecystectomy alters the bile flow into the intestine and the enterohepatic circulation of the bile acids; this may affect the gut microbiota. We assessed the gut microbiota composition of patients who had undergone cholecystectomy and compared with those who had not. From a cohort of 1463 adult participants who underwent comprehensive health screening examinations, 27 subjects who had undergone cholecystectomy (cholecystectomy group) and 81 age- and sex-matched subjects who had not (control group) were selected. Clinical parameters were collected and compared. Microbial composition was determined by 16S rRNA gene sequencing of DNA extracted from fecal samples. We evaluated differences in the overall microbial composition and in the abundance of taxa. The two groups were comparable with respect to clinical characteristics and laboratory results. The actual number of taxa observed in a sample (observed features) was significantly lower in the cholecystectomy group than in the control group (p = 0.042). The beta diversity of Jaccard distance index was significantly different between the two groups (p = 0.027). Blautia obeum and Veillonella parvula were more abundant in the cholecystectomy group. The difference in the diversity of the gut microbiota between the cholecystectomy and control groups was subtle. However, B. obeum and V. parvula, which have azoreductase activity, were more abundant in the cholecystectomy group. The impact of such changes in the gut microbiota on health remains to be determined.
DOI
10.3390/jcm8010079
Appears in Collections:
의과대학 > 의학과 > Journal papers
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