Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장준 | * |
dc.date.accessioned | 2019-01-28T16:30:05Z | - |
dc.date.available | 2019-01-28T16:30:05Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 0166-3542 | * |
dc.identifier.issn | 1872-9096 | * |
dc.identifier.other | OAK-24269 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/248294 | - |
dc.description.abstract | Nucleoprotein is highly conserved among each type of influenza viruses (A and B) and has received significant attention as a good target for universal influenza vaccine. In this study, we determined whether a recombinant adenovirus encoding nucleoprotein of type B influenza virus (rAd/B-NP) confers protection against influenza virus infection in mice. We also identified a cytotoxic T lymphocyte epitope in the nucleoprotein to determine B-NP-specific CD8 T-cell responses. We found that B-NP-specific CD8 T cells induced by rAd/B-NP immunization played a major role in protection following influenza B virus infection using CD8 knockout mice. To assess the effects of the administration routes on protective immunity, we immunized mice with rAd/B-NP via intranasal or intramuscular routes. Both groups showed strong NP-specific humoral and CD8 T-cell responses, but only intranasal immunization provided complete protection against both lineages of influenza B virus challenge. Intranasal but not intramuscular administration established resident memory CD8 T cells in the airway and lung parenchyma, which were required for efficient protection. Furthermore, rAd/B-NP in combination with rAd/A-NP protected mice against lethal infection with both influenza A and B viruses. These findings demonstrate that rAd/B-NP could be further developed as a universal vaccine against influenza. | * |
dc.language | English | * |
dc.publisher | ELSEVIER SCIENCE BV | * |
dc.subject | Influenza B virus | * |
dc.subject | Vaccine | * |
dc.subject | Nucleoprotein | * |
dc.subject | Mucosal immunization | * |
dc.subject | Protection | * |
dc.title | Single mucosal vaccination targeting nucleoprotein provides broad protection against two lineages of influenza B virus | * |
dc.type | Article | * |
dc.relation.volume | 163 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 19 | * |
dc.relation.lastpage | 28 | * |
dc.relation.journaltitle | ANTIVIRAL RESEARCH | * |
dc.identifier.doi | 10.1016/j.antiviral.2019.01.002 | * |
dc.identifier.wosid | WOS:000459843400003 | * |
dc.identifier.scopusid | 2-s2.0-85059850636 | * |
dc.author.google | Kim, Myung Hee | * |
dc.author.google | Kang, Jung-Ok | * |
dc.author.google | Kim, Joo-Young | * |
dc.author.google | Jun, Hi Eun | * |
dc.author.google | Lee, Heung Kyu | * |
dc.author.google | Chang, Jun | * |
dc.contributor.scopusid | 장준(8735999100) | * |
dc.date.modifydate | 20231120165756 | * |