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CHA(2)DS(2)-VASc score predicts exercise intolerance in young and middle-aged male patients with asymptomatic atrial fibrillation

Title
CHA(2)DS(2)-VASc score predicts exercise intolerance in young and middle-aged male patients with asymptomatic atrial fibrillation
Authors
Yi, Jeong-EunLee, Young SooChoi, Eue-KeunCha, Myung-JinKim, Tae-HoonPark, Jin-KyuLee, Jung-MyungKang, Ki-WoonShim, JaeminUhm, Jae-SunKim, JunKim, ChangsooKim, Jin-BaePark, Hyung WookJoung, BoyoungPark, Junbeom
Ewha Authors
박준범이정은
SCOPUS Author ID
박준범scopus; 이정은scopus
Issue Date
2018
Journal Title
SCIENTIFIC REPORTS
ISSN
2045-2322JCR Link
Citation
SCIENTIFIC REPORTS vol. 8
Publisher
NATURE PUBLISHING GROUP
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Exercise intolerance among the clinical symptoms in patients with atrial fibrillation (AF) has usually been masked by their adjusted life style. We sought to assess the role of CHA(2)DS(2)-VASc score to predict exercise intolerance in asymptomatic AF patients, and further examine whether the relationship differs by age and gender. Among the 6,275 participants of the prospective Korean registry of the Comparison study of Drugs for symptom control and complication prevention of Atrial Fibrillation (CODE-AF), 1,080 AF patients who underwent exercise treadmill testing were studied. Exercise intolerance was defined as a peak exercise capacity of 7 metabolic equivalents (METs) or less, and the patients were divided into two groups for the analysis: <= 7 METs (n = 131) and >7 METs (n = 949). Patients with exercise intolerance had a significantly higher CHA(2)DS(2)-VASc score than those without (3.1 +/- 1.3 vs. 2.0 +/- 1.5, p < 0.0001). In the multivariate analysis, a higher CHA(2)DS(2)-VASc score (OR 1.54, 95% CI 1.31-1.81, p < 0.0001), corrected QT interval (OR 1.01, 95% CI 1.00-1.02, p = 0.026), and increased left atrial volume index (OR 1.02, 95% CI 1.01-1.03, p = 0.001) were found to be independent predictors of exercise intolerance. The impact of the CHA(2)DS(2)-VASc score on exercise intolerance was significant only in male patients aged < 65 years (OR 3.30, 95% CI 1.76-6.19, p < 0.0001). The CHA(2)DS(2)-VASc score may be a feasible risk assessment tool to predict exercise intolerance, especially in young and middle-aged male patients with asymptomatic AF.
DOI
10.1038/s41598-018-36185-7
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의과대학 > 의학과 > Journal papers
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