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Perinatal Exposure to Arsenic in Drinking Water Alters Glutamatergic Neurotransmission in the Striatum of C57BL/6 Mice

Title
Perinatal Exposure to Arsenic in Drinking Water Alters Glutamatergic Neurotransmission in the Striatum of C57BL/6 Mice
Authors
Sung, KyunghwaKim, MinjeongKim, HaesooHwang, Gi-WookKim, Kisok
Ewha Authors
김민정
Issue Date
2019
Journal Title
BIOLOGICAL TRACE ELEMENT RESEARCH
ISSN
0163-4984JCR Link

1559-0720JCR Link
Citation
BIOLOGICAL TRACE ELEMENT RESEARCH vol. 187, no. 1, pp. 224 - 229
Keywords
ArsenicGlutamatemGluR2mGluR3StriatumVGLUT2
Publisher
HUMANA PRESS INC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Although exposure to arsenic (As) induces developmental neurotoxicity, there is a lack of data regarding its specific effects on glutamatergic neurotransmission in offspring from dams exposed to As during gestation and lactation. In this study, the body weight, glutamate content, and expression of vesicular glutamate transporter 2 (VGLUT2) and metabotropic glutamate receptors mGluR2 and mGluR3 was examined in the striatum of offspring following treatment of the dams with As (10 or 100mg/L NaAsO2 in drinking water). At postnatal day 21, body weight was decreased significantly, whereas the glutamate content in the striatum of offspring in the 100-mg/L As group were not significantly different from those in the control group. Although mGluR3 expression was not significantly different, VGLUT2 and mGluR2 expression was significantly lower in the striatum of offspring of As-exposed dams. These data indicate that altered glutamatergic neurotransmission may contribute to As-induced developmental neurotoxic effects.
DOI
10.1007/s12011-018-1374-2
Appears in Collections:
연구기관 > 약학연구소 > Journal papers
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