Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 오세관 | * |
dc.date.accessioned | 2019-01-24T16:30:06Z | - |
dc.date.available | 2019-01-24T16:30:06Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1860-8965 | * |
dc.identifier.other | OAK-24178 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/248208 | - |
dc.description.abstract | Purpose: Significant disturbances of the classical amphetamines on the dopamine (DA) and serotonin (5-HT) systems have been previously reported. However, few studies have been conducted on the effects of new psychoactive phenethylamines on the release of DA and 5-HT. In the present study, the effects of new psychoactive phenethylamines with a variety of aromatic ring substitutions (5-API, 3-FMA, 5-MAPB, and DMMA) on the release of DA and 5-HT were investigated. Methods: Changes of DA, 5-HT and their metabolites in brain microdialysates from rats following exposure to the drugs were examined using a validated liquid chromatography–tandem mass spectrometry method. Their potencies of DA and 5-HT uptake inhibition as well as dopamine transporter (DAT) and serotonin transporter (SERT) binding were also determined. Results: With the exception of DMMA, the drugs markedly affected the extracellular concentration of DA, 5-HT and/or their metabolites in rats and acted as potent inhibitors for DAT and/or SERT. Especially, 5-API potently induced the nonselective release of both DA and 5-HT, which was strongly correlated with a high degree of uptake inhibition and binding affinity to DAT and SERT. The 3-FMA, a methamphetamine analog with a halogen-substituted benzene, induced greater 5-HT release than DA. Conclusions: We found that new psychoactive phenethylamines, with a variety of aromatic ring substitutions, affected the extracellular levels of DA, 5-HT, and/or their metabolites in the nucleus accumbens of rats to varying degrees and in different ways. The current results may assist further research into monoamine neurotransmitter-related mechanisms of new psychoactive phenethylamines. Graphical abstract: [Figure not available: see fulltext.]. © 2018, Japanese Association of Forensic Toxicology and Springer Japan KK, part of Springer Nature. | * |
dc.language | English | * |
dc.publisher | Springer Tokyo | * |
dc.subject | Aromatic ring-substituted phenethylamines | * |
dc.subject | DA and 5-HT transporters | * |
dc.subject | Dopamine (DA) and serotonin (5-HT) | * |
dc.subject | Drug abuse | * |
dc.subject | Microdialysis | * |
dc.subject | New psychoactive substances (NPS) | * |
dc.title | Effects of aromatic ring-substituted phenethylamines on the release of dopamine and serotonin | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 37 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 104 | * |
dc.relation.lastpage | 112 | * |
dc.relation.journaltitle | Forensic Toxicology | * |
dc.identifier.doi | 10.1007/s11419-018-0440-y | * |
dc.identifier.wosid | WOS:000455068800010 | * |
dc.identifier.scopusid | 2-s2.0-85052948103 | * |
dc.author.google | Kim M. | * |
dc.author.google | Yang C.H. | * |
dc.author.google | Lee Y.S. | * |
dc.author.google | Jang C.-G. | * |
dc.author.google | Oh S. | * |
dc.author.google | Lee S. | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.date.modifydate | 20240118133340 | * |