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Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice

Title
Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice
Authors
Choi, YunsikLee, SanghyukKim, KapyoulKim, Soo-HyunChung, Yeun-JunLee, Charles
Ewha Authors
이상혁Charles Lee
SCOPUS Author ID
이상혁scopus; Charles Leescopus
Issue Date
2018
Journal Title
EXPERIMENTAL AND MOLECULAR MEDICINE
ISSN
1226-3613JCR Link

2092-6413JCR Link
Citation
EXPERIMENTAL AND MOLECULAR MEDICINE vol. 50
Publisher
NATURE PUBLISHING GROUP
Indexed
SCI; SCIE; SCOPUS; KCI WOS
Document Type
Review
Abstract
Cancer immunotherapy is a promising way to eliminate tumor cells by using the patient's own immune system. Selecting the appropriate animal models to develop or validate preclinical immunotherapeutic trials is now an important aspect of many cancer research programs. Here we discuss the advantages and limitations of using genetically engineered immunodeficient mouse models, patient-derived xenografts (PDXs), and humanized mouse models for developing and testing immunotherapeutic strategies.
DOI
10.1038/s12276-018-0115-0
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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