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Association between Cigarette Smoking Status and Composition of Gut Microbiota: Population-Based Cross-Sectional Study

Title
Association between Cigarette Smoking Status and Composition of Gut Microbiota: Population-Based Cross-Sectional Study
Authors
Lee, Su HwanYun, YeojunKim, Soo JungLee, Eun-JuChang, YoosooRyu, SeunghoShin, HocheolKim, Hyung-LaeKim, Han-NaLee, Jin Hwa
Ewha Authors
김형래이진화김수정이수환
SCOPUS Author ID
김형래scopus; 이진화scopus; 김수정scopus
Issue Date
2018
Journal Title
JOURNAL OF CLINICAL MEDICINE
ISSN
2077-0383JCR Link
Citation
JOURNAL OF CLINICAL MEDICINE vol. 7, no. 9
Keywords
cigarette smokingmicrobiotagastrointestinal microbiome16S rRNA
Publisher
MDPI
Indexed
SCOPUS WOS
Document Type
Article
Abstract
There have been few large-scale studies on the relationship between smoking and gut microbiota. We investigated the relationship between smoking status and the composition of gut microbiota. This was a population-based cross-sectional study using Healthcare Screening Center cohort data. A total of 758 men were selected and divided into three groups: never (n = 288), former (n = 267), and current smokers (n = 203). Among the three groups, there was no difference in alpha diversity, however, Jaccard-based beta diversity showed significant difference (p = 0.015). Pairwise permutational multivariate analysis of variance (PERMANOVA) tests between never and former smokers did not show a difference; however, there was significant difference between never and current smokers (p = 0.017) and between former and current smokers (p = 0.011). Weighted UniFrac-based beta diversity also showed significant difference among the three groups (p = 0.038), and pairwise PERMANOVA analysis of never and current smokers showed significant difference (p = 0.01). In the analysis of bacterial composition, current smokers had an increased proportion of the phylum Bacteroidetes with decreased Firmicutes and Proteobacteria compared with never smokers, whereas there were no differences between former and never smokers. In conclusion, gut microbiota composition of current smokers was significantly different from that of never smokers. Additionally, there was no difference in gut microbiota composition between never and former smokers.
DOI
10.3390/jcm7090282
Appears in Collections:
의과대학 > 의학과 > Journal papers
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