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Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis
- Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis
- Altinel, Yuksel; Chung, Soon Soup; Okay, Guven; Ugras, Nesrin; Isik, Ahmet Fatih; Ozturk, Ersin; Ozguc, Halil
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
- ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY vol. 24, no. 5, pp. 405 - 411
- Anastomosis; chitosan; PDS suture; tensile strength; Vicryl suture; wound healing
- TURKISH ASSOC TRAUMA EMERGENCY SURGERY
- SCIE; SCOPUS
- Document Type
- BACKGROUND: We evaluated the feasibility of chitosan-coated sutures for intestinal anastomosis strength through wound-healing effect. METHODS: Vicryl and PDS sutures were coated with 2% chitosan. While laparotomy was applied to the first group, chitosan was applied in the peritoneal cavity in the second group. Then the following materials were applied to colon anastomosis, in order: Vicryl, PDS, chitosan-coated Vicryl, and chitosan-coated PDS sutures. On the 7th and 14th days, eight rats from each group were euthanized. RESULTS: The adhesion scores of chitosan and control groups were lower than the suture groups. The vascularization of Vicryl-chitosan was lower than PDS-chitosan on the 14th day (p=0.038). Fibroblast cells and vascularization of anastomosis with chitosan-coated Vicryl were lower than Vicryl and chitosan-coated PDS on the 14th day (p<0.05). The tensile strength of Vicryl-chitosan increased more than Vicryl in vitro (p<0.05) on the 14th and 7th days, but there was no difference in vivo. The tensile strength of PDS-chitosan decreased more than PDS on the 7th day in vivo (p<0.05). CONCLUSION: The chitosan-coating effect on the adhesion and reinforcement of anastomosis in some parts of Vicryl in vitro and PDS in vivo was slightly improved.
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