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Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis

Title
Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis
Authors
Altinel, YukselChung, Soon SoupOkay, GuvenUgras, NesrinIsik, Ahmet FatihOzturk, ErsinOzguc, Halil
Ewha Authors
정순섭
SCOPUS Author ID
정순섭scopus
Issue Date
2018
Journal Title
ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
ISSN
1306-696XJCR Link
Citation
ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY vol. 24, no. 5, pp. 405 - 411
Keywords
AnastomosischitosanPDS suturetensile strengthVicryl suturewound healing
Publisher
TURKISH ASSOC TRAUMA EMERGENCY SURGERY
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
BACKGROUND: We evaluated the feasibility of chitosan-coated sutures for intestinal anastomosis strength through wound-healing effect. METHODS: Vicryl and PDS sutures were coated with 2% chitosan. While laparotomy was applied to the first group, chitosan was applied in the peritoneal cavity in the second group. Then the following materials were applied to colon anastomosis, in order: Vicryl, PDS, chitosan-coated Vicryl, and chitosan-coated PDS sutures. On the 7th and 14th days, eight rats from each group were euthanized. RESULTS: The adhesion scores of chitosan and control groups were lower than the suture groups. The vascularization of Vicryl-chitosan was lower than PDS-chitosan on the 14th day (p=0.038). Fibroblast cells and vascularization of anastomosis with chitosan-coated Vicryl were lower than Vicryl and chitosan-coated PDS on the 14th day (p<0.05). The tensile strength of Vicryl-chitosan increased more than Vicryl in vitro (p<0.05) on the 14th and 7th days, but there was no difference in vivo. The tensile strength of PDS-chitosan decreased more than PDS on the 7th day in vivo (p<0.05). CONCLUSION: The chitosan-coating effect on the adhesion and reinforcement of anastomosis in some parts of Vicryl in vitro and PDS in vivo was slightly improved.
DOI
10.5505/tjtes.2018.59280
Appears in Collections:
의과대학 > 의학과 > Journal papers
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