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Factors Associated with Early Mortality in Critically Ill Patients Following the Initiation of Continuous Renal Replacement Therapy

Title
Factors Associated with Early Mortality in Critically Ill Patients Following the Initiation of Continuous Renal Replacement Therapy
Authors
Kee, Youn KyungKim, DahyeKim, Seung-JungKang, Duk-HeeChoi, Kyu BokOh, Hyung JungRyu, Dong-Ryeol
Ewha Authors
강덕희최규복김승정류동열
SCOPUS Author ID
강덕희scopus; 최규복scopus; 김승정scopus; 류동열scopus
Issue Date
2018
Journal Title
JOURNAL OF CLINICAL MEDICINE
ISSN
2077-0383JCR Link
Citation
JOURNAL OF CLINICAL MEDICINE vol. 7, no. 10
Keywords
continuous renal replacement therapyearly mortalityclinical illness
Publisher
MDPI
Indexed
SCOPUS WOS
Document Type
Article
Abstract
Continuous renal replacement therapy (CRRT) is an important modality to support critically ill patients, and the need for CRRT treatment has been increasing. However, CRRT management is costly, and the associated resources are limited. Thus, it remains challenging to identify patients that are likely to have a poor outcome, despite active treatment with CRRT. We sought to elucidate the factors associated with early mortality after CRRT initiation. We analyzed 240 patients who initiated CRRT at an academic medical center between September 2016 and January 2018. We compared baseline characteristics between patients who died within seven days of initiating CRRT (early mortality), and those that survived more than seven days beyond the initiation of CRRT. Of the patients assessed, 130 (54.2%) died within seven days of CRRT initiation. Multivariate logistic regression models revealed that low mean arterial pressure, low arterial pH, and high Sequential Organ Failure Assessment score before CRRT initiation were significantly associated with increased early mortality in patients requiring CRRT. In conclusion, the mortality within seven days following CRRT initiation was very high in this study. We identified several factors that are associated with early mortality in patients undergoing CRRT, which may be useful in predicting early outcomes, despite active treatment with CRRT.
DOI
10.3390/jcm7100334
Appears in Collections:
의과대학 > 의학과 > Journal papers
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