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Endoplasmic Reticulum-Targeted Ratiometric N-Heterocyclic Carbene Borane Probe for Two-Photon Microscopic Imaging of Hypochlorous Acid

Title
Endoplasmic Reticulum-Targeted Ratiometric N-Heterocyclic Carbene Borane Probe for Two-Photon Microscopic Imaging of Hypochlorous Acid
Authors
Pak, Yen LengPark, Sang JunSong, GyeongokYim, YubinKang, HyukKim, Hwan MyungBoufard, JeanYoon, Juyoung
Ewha Authors
윤주영Jean Bouffard
SCOPUS Author ID
윤주영scopus; Jean Bouffardscopus
Issue Date
2018
Journal Title
ANALYTICAL CHEMISTRY
ISSN
0003-2700JCR Link

1520-6882JCR Link
Citation
ANALYTICAL CHEMISTRY vol. 90, no. 21, pp. 12937 - 12943
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS
Document Type
Article
Abstract
The naphthoimidazolium borane 4 is shown to be a selective probe for HOCl over other reactive oxygen species. Unlike other boronate-reactive oxygen species (ROS) fluorogenic probes that are oxidized by HOCl through a nucleophilic borono-Dakin oxidation mechanism, probe 4 is distinguished by its electrophilic oxidation mechanism involving B-H bond cleavage. Two-photon microscopy experiments in living cells and tissues with the probe 4 demonstrate the monitoring of endogenous HOCl generation and changes in HOCl concentrations generated in the endoplasmic reticulum during oxidative stress situations.
DOI
10.1021/acs.analchem.8b03565
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자연과학대학 > 화학·나노과학전공 > Journal papers
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