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Endoplasmic Reticulum-Targeted Ratiometric N-Heterocyclic Carbene Borane Probe for Two-Photon Microscopic Imaging of Hypochlorous Acid
- Title
- Endoplasmic Reticulum-Targeted Ratiometric N-Heterocyclic Carbene Borane Probe for Two-Photon Microscopic Imaging of Hypochlorous Acid
- Authors
- Pak, Yen Leng; Park, Sang Jun; Song, Gyeongok; Yim, Yubin; Kang, Hyuk; Kim, Hwan Myung; Boufard, Jean; Yoon, Juyoung
- Ewha Authors
- 윤주영; Jean Bouffard
- SCOPUS Author ID
- 윤주영; Jean Bouffard
- Issue Date
- 2018
- Journal Title
- ANALYTICAL CHEMISTRY
- ISSN
- 0003-2700
1520-6882
- Citation
- ANALYTICAL CHEMISTRY vol. 90, no. 21, pp. 12937 - 12943
- Publisher
- AMER CHEMICAL SOC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The naphthoimidazolium borane 4 is shown to be a selective probe for HOCl over other reactive oxygen species. Unlike other boronate-reactive oxygen species (ROS) fluorogenic probes that are oxidized by HOCl through a nucleophilic borono-Dakin oxidation mechanism, probe 4 is distinguished by its electrophilic oxidation mechanism involving B-H bond cleavage. Two-photon microscopy experiments in living cells and tissues with the probe 4 demonstrate the monitoring of endogenous HOCl generation and changes in HOCl concentrations generated in the endoplasmic reticulum during oxidative stress situations.
- DOI
- 10.1021/acs.analchem.8b03565
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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