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The Prevalence of Cerebra Microbleeds in Non-Demented Parkinson's Disease Patients

Title
The Prevalence of Cerebra Microbleeds in Non-Demented Parkinson's Disease Patients
Authors
Kim, Kyeong JoonBae, Yun JungKim, Jong-MinKim, Beom JoonOh, Eung SeokYun, Ji YoungKim, Ji SeonKim, Han-Joon
Ewha Authors
윤지영
SCOPUS Author ID
윤지영scopusscopus
Issue Date
2018
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
1011-8934JCR Link

1598-6357JCR Link
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE vol. 33, no. 46
Keywords
Cerebral MicrobleedsParkinson's DiseaseSynucleinopathyAmyloid Angiopathy
Publisher
KOREAN ACAD MEDICAL SCIENCES
Indexed
SCIE; SCOPUS; KCI WOS
Document Type
Article
Abstract
Background: Cerebral microbleeds (CMBs) are associated with cerebrovascular risk factors and cognitive dysfunction among patients with Parkinson's disease (PD). However, whether CMBs themselves are associated with PD is to be elucidated. Methods: We analyzed the presence of CMBs using 3-Tesla brain magnetic resonance imaging in non-demented patients with PD and in age-, sex-, and hypertension-matched control subjects. PD patients were classified according to their motor subtypes: tremor-dominant, intermediate, and postural instability-gait disturbance (PIGD). Other cerebrovascular risk factors and small vessel disease (SVD) burdens were also evaluated. Results: Two-hundred and five patients with PD and 205 control subjects were included. The prevalence of CMBs was higher in PD patients than in controls (16.1% vs. 8.8%; odds ratio [OR], 2.126; P= 0.019); CMBs in the lobar area showed a significant difference between PD patients and controls (11.7% vs. 5.9%; OR, 2.234; P= 0.032). According to the motor subtype, CMBs in those with PIGD type showed significant difference from controls with respect to the overall brain area (21.1% vs. 8.9%; OR, 2.759; P= 0.010) and lobar area (14.6% vs. 4.9%; OR, 3.336; P= 0.016). Among PD patients, those with CMBs had higher age and more evidence of SVDs than those without CMBs. Conclusion: We found that CMBs are more frequent in PD patients than in controls, especially in those with the PIGD subtype and CMBs on the lobar area. Further study investigating the pathogenetic significance of CMBs is required.
DOI
10.3346/jkms.2018.33.e289
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의료원 > 의료원 > Journal papers
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