Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정지향 | * |
dc.date.accessioned | 2018-12-31T16:30:19Z | - |
dc.date.available | 2018-12-31T16:30:19Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 1387-2877 | * |
dc.identifier.issn | 1875-8908 | * |
dc.identifier.other | OAK-23565 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247992 | - |
dc.description.abstract | Background: There is a lack of research on the effects of physical activity (PA) on the progression of Alzheimer's disease (AD). Objectives: We investigated whether PA is associated with progression of dementia and mortality in AD. Methods: In the present study, 934 patients with mild-to-moderate AD were included. PA was evaluated using a questionnaire written by the caregiver. The outcome measures were the Clinical Dementia Rating-Sum of Boxes (CDR-SB), Seoul-Instrumental Activities of Daily Living (S-IADL), Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI), a global composite score of neuropsychological subtests, and mortality. They were evaluated annually and received a maximum of three follow-up examinations. Results: Between-group differences compared with the no PA group in the change of CDR-SB scores were -0.431 (95% CI = -0.824 similar to-0.039; p = 0.031) for the moderate PA group (150-750 minutes per week of moderate intensity PA), and -1.148 (-1.656 similar to-0.639; p < 0.001) for the high PA group (>750 minutes per week). As PA increased, there was a significant trend to slow the rate of increase in the CDR-SB, S-IADL, and CGA-NPI scores. The patients with >= 150 minutes per week for each of non-recreational and recreational PAs had a lower risk of mortality compared to those with <150 minutes per week for each of the PAs (hazard ratio 0.22, 95% CI = 0.05 similar to 0.88; p = 0.033). Conclusion: More PA is associated with slower progression of dementia severity, functional decline, and abnormal behavior, and with a lower risk of mortality in AD. | * |
dc.language | English | * |
dc.publisher | IOS PRESS | * |
dc.subject | Alzheimer's disease | * |
dc.subject | dementia | * |
dc.subject | physical activity | * |
dc.subject | progression | * |
dc.subject | mortality | * |
dc.title | Effect of Physical Activity on the Progression of Alzheimer's Disease: The Clinical Research Center for Dementia of South Korea Study | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 66 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 249 | * |
dc.relation.lastpage | 261 | * |
dc.relation.journaltitle | JOURNAL OF ALZHEIMERS DISEASE | * |
dc.identifier.doi | 10.3233/JAD-180333 | * |
dc.identifier.wosid | WOS:000448213400014 | * |
dc.identifier.scopusid | 2-s2.0-85055140592 | * |
dc.author.google | Minn, Yang-Ki | * |
dc.author.google | Choi, Seong Hye | * |
dc.author.google | Suh, Young Ju | * |
dc.author.google | Jeong, Jee Hyang | * |
dc.author.google | Kim, Eun-Joo | * |
dc.author.google | Kim, Jong Hun | * |
dc.author.google | Park, Kyung Won | * |
dc.author.google | Park, Moon Ho | * |
dc.author.google | Youn, Young Chul | * |
dc.author.google | Yoon, Bora | * |
dc.author.google | Choi, Seok-Jin | * |
dc.author.google | Oh, Youn Kyung | * |
dc.author.google | Yoon, Soo Jin | * |
dc.contributor.scopusid | 정지향(7402045750;57192068764) | * |
dc.date.modifydate | 20240123101416 | * |