Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김호성 | - |
dc.date.accessioned | 2018-12-27T16:30:07Z | - |
dc.date.available | 2018-12-27T16:30:07Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0378-8512 | - |
dc.identifier.other | OAK-16993 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247970 | - |
dc.description.abstract | The insulin-like growth factor binding protein (IGFBP) family is a critical component of the insulin-like growth factor (IGF) system which regulate the biological actions of the IGFs and may also be capable of IGF-independent actions. To date, seven distinct IGFBPs have been described. Among these IGFBPs, IGFBPs-1-6 bind IGFs with high affinity, while only IGFBP-7 binds with low affinity. Recently, we have demonstrated that connective tissue growth factor (CTGF) also binds IGFs with low affinity, suggesting that a family of low-affinity IGFBPs, distinct from the high-affinity members, may exist, and together these constitute an IGFBP superfamily. IGFBPs have various biological roles. IGFBPs act not only as a carrier proteins, but also as a modulators of IGF actions by involving in IGF ligand-receptor interactions through influences on both the bioavailability and distribution of IGFs in the extracellular environment. In addition, some IGFBPs (IGFBPs-1, -3, and -5) appears to have intrinsic activity independent of IGFs. This review will focus on recent studies on the biological roles of IGFBPs in IGF-dependent and IGF-independent modes. | - |
dc.language | English | - |
dc.title | Biological roles of insulin-like growth factor binding proteins (IGFBPs) | - |
dc.type | Review | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 29 | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 85 | - |
dc.relation.lastpage | 96 | - |
dc.relation.journaltitle | Experimental and Molecular Medicine | - |
dc.identifier.scopusid | 2-s2.0-0030849348 | - |
dc.author.google | Kim H.-S. | - |
dc.author.google | Rosenfeld R.G. | - |
dc.author.google | Oh Y. | - |
dc.date.modifydate | 20181227114532 | - |