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The Reaction of 6,7-Dichloro-5,8-quinoxalinedione with Aromatic and Aliphatic Dinucleophiles and Molecular Modeling Study, of Their Intercalation Complexes

Title
The Reaction of 6,7-Dichloro-5,8-quinoxalinedione with Aromatic and Aliphatic Dinucleophiles and Molecular Modeling Study, of Their Intercalation Complexes
Authors
Yoo H.-W.Suh M.-E.Shin K.J.Park S.-W.
Ewha Authors
서명은유희원
SCOPUS Author ID
서명은scopus
Issue Date
1997
Journal Title
Bulletin of the Korean Chemical Society
ISSN
0253-2964JCR Link
Citation
Bulletin of the Korean Chemical Society vol. 18, no. 5, pp. 484 - 488
Indexed
SCI; SCIE; SCOPUS; KCI scopus
Document Type
Article
Abstract
The angular and planar heterocyclic compounds containing nitrogen, sulfur and oxygen were synthesized by reaction of 6,7-dichloro-5,8-quinoxalinedione with aromatic and aliphatic dinucleophiles. Nucleophilic reactivity was somewhat different between 2,3-dichloro-1,4-naphthoquinone and 6,7-dichloro-5,8-quinolinedione with dinucleophiles. The distribution of electron in heterocycle appeared to contribute to this difference. The intercalation comple of planar heterocyclic compound between GC/GC base pairs showed the optimum intercalation but the intercalation of angular heterocyclic compound was not good. Thus, the planar compound was expected to have antitumor activity.
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약학대학 > 약학과 > Journal papers
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