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dc.contributor.author함정희-
dc.date.accessioned2018-12-27T16:30:04Z-
dc.date.available2018-12-27T16:30:04Z-
dc.date.issued2000-
dc.identifier.issn0494-4739-
dc.identifier.otherOAK-17161-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/247954-
dc.description.abstractSystemic PUVA therapy can produce various acute reactions and potential long-term damage including benign and malignant skin tumors. Obviously the risk is related to DNA damage, but PUVA-induced down-regulation of immune responses may play an additional role. Keratoacanthoma is etiologically related to sunlight and immunosuppression. PUVA keratoses are raised warty papules with a broad base and a diameter of several millimeters to 1 centimeter, and they are associated with an increased risk of nonmelanoma skin cancer. We report a case of solitary keratoacanthoma and multiple PUVA keratoses all developing in vitiliginous areas in a patient receiving long-term, high-dose PUVA therapy for generalized vitiligo. A 57-year-old Korean female, who had undergone intermittent systemic PUVA therapy for 11 years, noted multiple asymptomatic, yellowish, hyperkeratotic papules on the dorsa of hands and feet 1 year previously, and a bean-sized raised painful nodule filled with keratin plug on the dorsum of right hand 1 month previously. Skin biopsy confirmed the diagnoses of PUVA keratoses and keratoacanthoma, respectively. PCR-SSCP analysis revealed no mutation of p53 tumor suppressor gene in this case.-
dc.languageKorean-
dc.titleKeratoacanthoma and PUVA keratoses in a vitiligo patient following oral psoralen photochemotherapy (PUVA)-
dc.typeArticle-
dc.relation.issue9-
dc.relation.volume38-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage1234-
dc.relation.lastpage1238-
dc.relation.journaltitleKorean Journal of Dermatology-
dc.identifier.scopusid2-s2.0-0033774157-
dc.author.googleKim S.-H.-
dc.author.googleKang M.-J.-
dc.author.googleCho S.-
dc.author.googleWhang K.-K.-
dc.author.googleHahln J.-H.-
dc.date.modifydate20181227103012-
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의과대학 > 의학과 > Journal papers
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