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Metabolic engineering of Corynebacterium glutamicum for fermentative production of chemicals in biorefinery

Title
Metabolic engineering of Corynebacterium glutamicum for fermentative production of chemicals in biorefinery
Authors
Baritugo K.-A.Kim H.T.David Y.Choi J.-I.Hong S.H.Jeong K.J.Choi J.H.Joo J.C.Park S.J.
Ewha Authors
박시재
SCOPUS Author ID
박시재scopus
Issue Date
2018
Journal Title
Applied Microbiology and Biotechnology
ISSN
0175-7598JCR Link
Citation
Applied Microbiology and Biotechnology vol. 102, no. 9, pp. 3915 - 3937
Keywords
Bio-based chemicalsCorynebacterium glutamicumMetabolic engineeringMicrobial cell factoryPlasmid vectorsPromoters
Publisher
Springer Verlag
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Bio-based production of industrially important chemicals provides an eco-friendly alternative to current petrochemical-based processes. Because of the limited supply of fossil fuel reserves, various technologies utilizing microbial host strains for the sustainable production of platform chemicals from renewable biomass have been developed. Corynebacterium glutamicum is a non-pathogenic industrial microbial species traditionally used for l-glutamate and l-lysine production. It is a promising species for industrial production of bio-based chemicals because of its flexible metabolism that allows the utilization of a broad spectrum of carbon sources and the production of various amino acids. Classical breeding, systems, synthetic biology, and metabolic engineering approaches have been used to improve its applications, ranging from traditional amino-acid production to modern biorefinery systems for production of value-added platform chemicals. This review describes recent advances in the development of genetic engineering tools and techniques for the establishment and optimization of metabolic pathways for bio-based production of major C2–C6 platform chemicals using recombinant C. glutamicum. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
DOI
10.1007/s00253-018-8896-6
Appears in Collections:
엘텍공과대학 > 화학신소재공학전공 > Journal papers
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