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Seroprevalence of opsonophagocytic antibodies against serotype Ia, Ib, II, III, and V Group B streptococcus among Korean population

Title
Seroprevalence of opsonophagocytic antibodies against serotype Ia, Ib, II, III, and V Group B streptococcus among Korean population
Authors
Lee J.H.Kim H.W.Kim K.-H.
Ewha Authors
김경효김한울
SCOPUS Author ID
김경효scopus; 김한울scopus
Issue Date
2018
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
Journal of Korean Medical Science vol. 33, no. 16
Keywords
AntibodiesPopulationPrevalenceSerotypeStreptococcus agalactiae
Publisher
Korean Academy of Medical Science
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
Background: Invasive Streptococcus agalactiae (group B streptococcus, GBS) infection most commonly occurs in infants; however, cases of GBS infection in adults, particularly in the elderly with significant underlying diseases, are being increasingly reported. We analyzed the serotype specific opsonophagocytic antibodies (the major mechanism of protection against GBS) in infants, adults, and the elderly. Methods: The opsonization indices (OIs) of antibodies against serotype Ia, Ib, II, III, and V GBS were studied in 89 infants, 35 adults (age, 30-50 years), and 62 elderly individuals (age, 65-85 years) according to the University of Alabama at Birmingham GBS opsonophagocytic killing assay protocol (www.vaccine.uab.edu). Results: In infants, adults, and elderly groups respectively, geometric mean of OI against GBS serotype Ia were 3, 7, and 32; against GBS serotype Ib were 7, 242, and 252; against serotype II were 93, 363, and 676; against serotype III were 8, 212, and 609; and against serotype V were 4, 639, and 610. The seropositive rate (% of subjects with OI = 4) increased significantly in older age group for all five serotypes. Conclusion: During infancy, only a limited proportion of infants have functional immunity against serotype Ia, Ib, II, III, and V GBS. Furthermore, a lack of opsonic activities against GBS observed in some adults and the elderly might predispose such individuals to the risk of invasive GBS infection. Epidemiological monitoring and development of suitable vaccine for these populations are needed. © 2018 The Korean Academy of Medical Sciences.
DOI
10.3346/jkms.2018.33.e127
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의과대학 > 의학과 > Journal papers
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