Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이지희 | * |
dc.contributor.author | 김희선 | * |
dc.contributor.author | 최지하 | * |
dc.contributor.author | 김민석 | * |
dc.date.accessioned | 2018-12-14T16:31:13Z | - |
dc.date.available | 2018-12-14T16:31:13Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 0741-5400 | * |
dc.identifier.issn | 1938-3673 | * |
dc.identifier.other | OAK-22438 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247851 | - |
dc.description.abstract | The signal transducer and activator of transcription 6 (STAT6) transcription factor activates peroxisome proliferator-activated receptor gamma (PPAR-)-regulated gene expression in immune cells. We investigated proximal membrane signaling that was initiated in macrophages after exposure to apoptotic cells that led to enhanced PPAR- expression and activity, using specific siRNAs for ABCA1, STAT6, and PPAR-, or their antagonists. The interactions between mouse bone marrow-derived macrophages or RAW 264.7 cells and apoptotic Jurkat cells, but not viable cells, resulted in the induction of STAT6 phosphorylation as well as PPAR- expression and activation. Knockdown of ATP-binding cassette transporter A1 (ABCA1) after the transfection of macrophages with ABCA1-specific siRNAs reduced apoptotic cell-induced STAT6 phosphorylation as well as PPAR- mRNA and protein expression. ABCA1 knockdown also reduced apoptotic cell-induced liver X receptor (LXR-) mRNA and protein expression. Moreover, inhibition of STAT6 with specific siRNAs or the pharmacological inhibitor AS1517499AS reversed the induction of PPAR-, LXR-, and ABCA1 by apoptotic Jurkat cells. PPAR--specific siRNAs or the PPAR- antagonist GW9662 inhibited apoptotic cell-induced increases in LXR- and ABCA1 mRNA and protein levels. Thus, these results indicate that apoptotic cells trigger the ABCA1/STAT6 pathway, leading to the activation of the PPAR-/LXR-/ABCA1 pathway in macrophages. The ABCA1-STAT6 pathway initiated by apoptotic cells is reinforced via a PPAR pathway. | * |
dc.language | English | * |
dc.publisher | WILEY | * |
dc.subject | bone marrow-derived macrophages | * |
dc.subject | mice | * |
dc.subject | proximal membrane signaling | * |
dc.subject | pulmonary fibrosis | * |
dc.title | Apoptotic cells trigger the ABCA1/STAT6 pathway leading to PPAR- expression and activation in macrophages | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 103 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 885 | * |
dc.relation.lastpage | 895 | * |
dc.relation.journaltitle | JOURNAL OF LEUKOCYTE BIOLOGY | * |
dc.identifier.doi | 10.1002/JLB.2A0817-341RR | * |
dc.identifier.wosid | WOS:000431501700009 | * |
dc.identifier.scopusid | 2-s2.0-85044578648 | * |
dc.author.google | Kim, Myeong-Joo | * |
dc.author.google | Lee, Ye-Ji | * |
dc.author.google | Yoon, Young-So | * |
dc.author.google | Kim, Minsuk | * |
dc.author.google | Choi, Ji Ha | * |
dc.author.google | Kim, Hee-Sun | * |
dc.author.google | Kang, Jihee Lee | * |
dc.contributor.scopusid | 이지희(7404517577) | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.contributor.scopusid | 최지하(35080057300) | * |
dc.contributor.scopusid | 김민석(55686393700) | * |
dc.date.modifydate | 20240222124201 | * |