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Gender affects prognosis of methicillin-resistant Staphylococcus aureus bacteremia differently depending on the severity of underlying disease
- Gender affects prognosis of methicillin-resistant Staphylococcus aureus bacteremia differently depending on the severity of underlying disease
- Kang, Chang Kyung; Kwak, Yee Gyung; Park, Youngmi; Song, Kyoung-Ho; Kim, Eu Suk; Jung, Sook-In; Park, Kyung-Hwa; Park, Wan Beom; Kim, Nam Joong; Kim, Young Keun; Jang, Hee-Chang; Lee, Shinwon; Jeon, Jae Hyun; Kwon, Ki Tae; Kim, Chung-Jong; Kim, Yeon-Sook; Kim, Hong Bin; Korea INfect Dis KIND Study Grp
- Ewha Authors
- Issue Date
- Journal Title
- EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
- EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES vol. 37, no. 6, pp. 1119 - 1123
- Gender; Underlying disease; MRSA; Bacteremia; Mortality
- SCI; SCIE; SCOPUS
- Document Type
- We aimed to elucidate the potential impact of gender on prognosis of Staphylococcus aureus bacteremia (SAB). We analyzed SAB cases prospectively collected over an 8-year period at 11 hospitals in Korea. SAB-related mortality was pre-defined as a death within 30 days from the onset of SAB without other apparent cause of death. The effect of gender on SAB-related mortality was examined in the entire cohort and in subgroups stratified according to methicillin resistance and Charlson's comorbidity-weighted index (CCWI) score. Those factors independently associated to SAB-related mortality were explored. Among 1974 eligible cases, SAB-related mortality rates in male and female were 21.2% (259/1224) and 21.9% (164/750), respectively (P = 0.786). The SAB-related mortality rate was independently higher in male than that in female in CCWI score <= 3 methicillin-resistant SAB (MRSAB) group (15.9 vs. 6.2%; aOR 3.65, 95% CI 1.46-9.13; P = 0.006) while the association tended to be inverse when CCWI score rises. Interaction between CCWI score and gender to MRSAB-related mortality was significant in multivariate analysis (aOR 0.85, 95% CI 0.74-0.96; P = 0.011). There was no significant interaction between gender and CCWI in entire SAB or methicillin-susceptible SAB cohorts. Gender may affect clinical outcomes of MRSAB differently depending on the severity of underlying disease.
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