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High dietary glycemic load is associated with poor functional outcome in patients with acute cerebral infarction

Title
High dietary glycemic load is associated with poor functional outcome in patients with acute cerebral infarction
Authors
Song T.-J.Chang Y.Chun M.-Y.Lee C.-Y.Kim A.-R.Kim Y.Kim Y.-J.
Ewha Authors
김용재김유리송태진
SCOPUS Author ID
김용재scopus; 김유리scopus; 송태진scopus
Issue Date
2018
Journal Title
Journal of Clinical Neurology (Korea)
ISSN
1738-6586JCR Link
Citation
Journal of Clinical Neurology (Korea) vol. 14, no. 2, pp. 165 - 173
Keywords
Carbohydrate intakeGlycemic indexGlycemic loadOutcomeStroke
Publisher
Korean Neurological Association
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
Background and Purpose Elevated postprandial blood glucose is a critical risk factor for stroke. The dietary glycemic load (GL) and glycemic index (GI) are frequently used as markers of the postprandial blood glucose response to estimate the overall glycemic effect of diets. We hypothesized that high dietary GL, GI, or total carbohydrate intake is associated with a poor functional outcome in patients with acute ischemic stroke. Methods We prospectively included 263 first-ever ischemic stroke patients who completed a semiquantitative food-frequency questionnaire. The dietary GL, GI, and total carbohydrate intake were investigated by examining the average frequency of intake during the previous year based on reference amounts for various food items. Poor functional outcome was defined as a score on the modified Rankin Scale (mRS) of ≥3 at 3 months after stroke. Results The patients were aged 65.4±11.7 years (mean±standard deviation), and 58.2% of them were male. A multivariate analysis adjusted for age, sex, marital status, prestroke mRS score, diabetes mellitus, hyperlipidemia, body mass index, triglycerides, low-density lipopro-tein, hemoglobin A1c, stroke classification, and National Institutes of Health Stroke Scale score, early neurological deterioration, and high-grade white-matter hyperintensities revealed that the dietary GL and total carbohydrate intake were associated with a poor functional outcome, with odds ratios for the top quartile relative to the bottom quartile of 28.93 (95% confidence interval= 2.82–296.04) and 36.84 (95% confidence interval=2.99–453.42), respectively (p for trend=0.002 and 0.002, respectively). In contrast, high dietary GI was not associated with a poor functional outcome (p for trend=0.481). Conclusions Increased dietary GL and carbohydrate intake were associated with a poor short-term functional outcome after an acute ischemic stroke. © 2018 Korean Neurological Association.
DOI
10.3988/jcn.2018.14.2.165
Appears in Collections:
의과대학 > 의학과 > Journal papers
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