Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.contributor.author | 임예현 | * |
dc.date.accessioned | 2018-12-14T16:31:08Z | - |
dc.date.available | 2018-12-14T16:31:08Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 1976-9148 | * |
dc.identifier.other | OAK-22470 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247823 | - |
dc.description.abstract | Sleep is the most basic and essential physiological requirement for mental health, and sleep disorders pose potential risks of metabolic and neurodegenerative diseases. Tryptic hydrolysate of αS1 -casein (αS1 -CH) has been shown to possess stress relieving and sleep promoting effects. However, the differential effects of αS1 -CH on electroencephalographic wave patterns and its effects on the protein levels of γ-aminobutyric acid A (GABAA) receptor subtypes in hypothalamic neurons are not well understood. We found αS1 -CH (120, 240 mg/kg) increased sleep duration in mice and reduced sleep-wake cycle numbers in rats. While αS1 -CH (300 mg/kg) increased total sleeping time in rats, it significantly decreased wakefulness. In addition, electroencephalographic theta (θ) power densities were increased whereas alpha (α) power densities were decreased by αS1 -CH (300 mg/kg) during sleep-wake cycles. Furthermore, protein expressions of GABAA receptor β1 subtypes were elevated in rat hypothalamus by αS1 -CH. These results suggest αS1 -CH, through GABAA receptor modulation, might be useful for treating sleep disorders. © 2018 The Korean Society of Applied Pharmacology. | * |
dc.language | English | * |
dc.publisher | Korean Society of Applied Pharmacology | * |
dc.subject | Electroencephalogram | * |
dc.subject | GABAA receptor | * |
dc.subject | Sleep | * |
dc.subject | αS1-CH | * |
dc.title | Administration of alphas1-casein hydrolysate increases sleep and modulates GABAA receptor subunit expression | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 26 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 268 | * |
dc.relation.lastpage | 273 | * |
dc.relation.journaltitle | Biomolecules and Therapeutics | * |
dc.identifier.doi | 10.4062/biomolther.2017.083 | * |
dc.identifier.wosid | WOS:000431656900004 | * |
dc.identifier.scopusid | 2-s2.0-85046800971 | * |
dc.author.google | Yayeh T. | * |
dc.author.google | Leem Y.-H. | * |
dc.author.google | Kim K.-M. | * |
dc.author.google | Jung J.-C. | * |
dc.author.google | Schwarz J. | * |
dc.author.google | Oh K.-W. | * |
dc.author.google | Oh S. | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.contributor.scopusid | 임예현(25422269100) | * |
dc.date.modifydate | 20240222143226 | * |