Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박상희 | * |
dc.contributor.author | 조성엽 | * |
dc.date.accessioned | 2018-12-14T16:31:05Z | - |
dc.date.available | 2018-12-14T16:31:05Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 0006-4971 | * |
dc.identifier.other | OAK-22503 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247803 | - |
dc.description.abstract | Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphomas (EBV1-DLBLs) tend to occur in immunocompromised patients, such as the elderly or those undergoing solid organ transplantation. The pathogenesis and genomic characteristics of EBV1-DLBLs are largely unknown because of the limited availability of human samples and lack of experimental animal models. We observed the development of 25 human EBV1-DLBLs during the engraftment of gastric adenocarcinomas into immunodeficient mice. An integrated genomic analysis of the human-derived EBV1-DLBLs revealed enrichment of mutations in Rho pathway genes, including RHPN2, and Rho pathway transcriptomic activation. Targeting the Rho pathway using a Rho-associated protein kinase (ROCK) inhibitor, fasudil, markedly decreased tumor growth in EBV1-DLBL patient-derived xenograft (PDX) models. Thus, alterations in the Rho pathway appear to contribute to EBV-induced lymphomagenesis in immunosuppressed environments. © 2018 by The American Society of Hematology. | * |
dc.description.sponsorship | Ministry of Science, ICT and Future Planning | * |
dc.language | English | * |
dc.publisher | American Society of Hematology | * |
dc.title | Alterations in the Rho pathway contribute to Epstein-Barr virus–induced lymphomagenesis in immunosuppressed environments | * |
dc.type | Article | * |
dc.relation.issue | 17 | * |
dc.relation.volume | 131 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1931 | * |
dc.relation.lastpage | 1941 | * |
dc.relation.journaltitle | Blood | * |
dc.identifier.doi | 10.1182/blood-2017-07-797209 | * |
dc.identifier.wosid | WOS:000431101100010 | * |
dc.identifier.scopusid | 2-s2.0-85047871272 | * |
dc.author.google | Cho S.-Y. | * |
dc.author.google | Sung C.O. | * |
dc.author.google | Chae J. | * |
dc.author.google | Lee J. | * |
dc.author.google | Na D. | * |
dc.author.google | Kang W. | * |
dc.author.google | Kang J. | * |
dc.author.google | Min S. | * |
dc.author.google | Lee A. | * |
dc.author.google | Kwak E. | * |
dc.author.google | Kim J. | * |
dc.author.google | Choi B. | * |
dc.author.google | Kim H. | * |
dc.author.google | Chuang J.H. | * |
dc.author.google | Pak H.-K. | * |
dc.author.google | Park C.-S. | * |
dc.author.google | Park S. | * |
dc.author.google | Ko Y.H. | * |
dc.author.google | Lee D. | * |
dc.author.google | Roh J. | * |
dc.author.google | Cho M.-S. | * |
dc.author.google | Ju Y.S. | * |
dc.author.google | Suh Y.-S. | * |
dc.author.google | Kong S.-H. | * |
dc.author.google | Lee H.-J. | * |
dc.author.google | Keck J. | * |
dc.author.google | Banchereau J. | * |
dc.author.google | Liu E.T. | * |
dc.author.google | Kim W.-H. | * |
dc.author.google | Park H. | * |
dc.author.google | Yang H.-K. | * |
dc.author.google | Kim J.-I. | * |
dc.author.google | Lee C. | * |
dc.contributor.scopusid | 박상희(12041890800) | * |
dc.contributor.scopusid | 조성엽(7404884433) | * |
dc.date.modifydate | 20240220112152 | * |