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Genetic structures of invasive Streptococcus pneumoniae isolates from Korean children obtained between 1995 and 2013

Title
Genetic structures of invasive Streptococcus pneumoniae isolates from Korean children obtained between 1995 and 2013
Authors
Yun K.W.Choi E.H.Lee H.J.Kang J.H.Kim K.-H.Kim D.S.Kim Y.-J.Eun B.W.Oh S.H.Cho H.-K.Hong Y.J.Kim K.N.Kim N.H.Kim Y.-K.Lee H.Lee T.Kim H.M.Cho E.Y.Kim C.S.Park S.E.Oh C.E.Jo D.S.Choi Y.Y.Lee J.
Ewha Authors
김경효
SCOPUS Author ID
김경효scopus
Issue Date
2018
Journal Title
BMC Infectious Diseases
ISSN
1471-2334JCR Link
Citation
BMC Infectious Diseases vol. 18, no. 1
Keywords
ChildrenInvasive pneumococcal diseasesMultilocus sequence typingPneumococcal conjugate vaccine
Publisher
BioMed Central Ltd.
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Background: Understanding the population genetics of pneumococci will allow detection of changes in the prevalence of circulating genotypes and evidence for capsular switching. We aimed to analyze the genetic structure of invasive pneumococcal isolates obtained from children before and after the use of pneumococcal conjugate vaccines (PCVs) in Korea. Methods: A total of 285 invasive pneumococcal isolates were analyzed using serotyping, multilocus sequence typing, and antimicrobial susceptibility testing. We classified the isolation year to pre-PCV7 (1995-2003; n = 70), post-PCV7 (2004-2010; n = 142), and post-PCV13 (2011-2013; n = 73) periods. Results: Of the 10 clonal complexes (CCs), antibiotic-resistant international clones, CC320 (31.6%), CC81 (14.7%), and CC166 (6.7%) were the main complexes. Serotype 19A was the main serotype of CC320 throughout the periods. Serotypes of CC81 mainly comprised of 23F (53.3%) in pre-PCV7 period and replaced by non-vaccine types (NVTs; 6C [10%], 13 [30%], 15A [40%], and 15B/C [20%]) in post-PCV13 period. The main serotype responsible for CC166 also changed from 9 V (80%) in pre-PCV7 to NVT 11A (50%) in post-PCV13 periods. Non-susceptibility to penicillin (42.3%) was the highest in CC320, increasing from 0 to 76%. Conclusion: The genetic structures of invasive pneumococcal isolates in Korean children have changed concomitantly with serotype after the implementation of PCVs. © 2018 The Author(s).
DOI
10.1186/s12879-018-3177-7
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의과대학 > 의학과 > Journal papers
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