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Gender-related differences in management of nonvalvular atrial fibrillation in an asian population

Title
Gender-related differences in management of nonvalvular atrial fibrillation in an asian population
Authors
Lee J.M.Kim T.-H.Cha M.-J.Park J.Park J.-K.Kang K.-W.Shim J.Uhm J.-S.Kim J.Park H.W.Lee Y.S.Choi E.-K.Kim C.-S.Joung B.Kim J.-B.
Ewha Authors
박준범
SCOPUS Author ID
박준범scopus
Issue Date
2018
Journal Title
Korean Circulation Journal
ISSN
1738-5520JCR Link
Citation
Korean Circulation Journal vol. 48, no. 6, pp. 519 - 528
Keywords
AnticoagulantsAsian ceancestry groupAtrial fbrillationRegistriesSex characteristics
Publisher
Korean Society of Circulation
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
Background and Objectives: Gender-related differences in health care utilization for atrial fbrillation (AF) are increasingly recognized. However, large cohort data for examining gender-related differences in AF are lacking in Asian populations. Methods: The Registry for Comparison Study of Drugs for Symptom Control and Complication Prevention of AF (CODE-AF Registry) is a prospective observational cohort-study that enrolled participants at 10 tertiary hospitals in South Korea. Baseline characteristics retrieved from the CODE-AF Registry were analyzed. Results: A total of 6,274 patients were recruited (mean age 67±11 years, mean CHA2DS2-VASc score 2.7±1.7, 63% male, 65% paroxysmal AF) from June 2016 to April 2017. Women underwent less electric cardioversion (12.3% vs. 19.6%, p<0.001), less radiofrequency ablation (12.4% vs. 17.9%, p<0.001), and less antiarrhythmic drug therapy (44.7% vs. 49.5%, p<0.001), despite having more severe symptoms (symptom class III or IV, 45.8% vs. 37.5%, p<0.001). Among patients with a CHA2DS2-VA score of 2 or more, a slightly higher proportion of women were taking oral anticoagulants than men (85.7% vs. 81.9%, p=0.002), and nonvitamin K antagonist oral anticoagulant (NOAC) use was more prevalent in women than men (70.4% vs. 62.3%, p<0.001). Insufcient NOAC dosing was very common, more so in women than men (61.5% vs. 56.3%, p<0.001). Conclusions: Female patients with AF were treated more conservatively and rhythm control strategies were used less frequently than in males, even though the female patients with AF had more severe symptoms. While insufcient NOAC dosing was common in both sex, it was signifcantly more frequent in women. © 2018 The Korean Society of Cardiology.
DOI
10.4070/kcj.2017.0389
Appears in Collections:
의과대학 > 의학과 > Journal papers
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