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Factors associated with rebleeding in patients with peptic ulcer bleeding: Analysis of the Korean peptic ulcer bleeding (K-PUB) study

Title
Factors associated with rebleeding in patients with peptic ulcer bleeding: Analysis of the Korean peptic ulcer bleeding (K-PUB) study
Authors
Kim J.S.Kim B.-W.Park S.M.Shim K.-N.Jeon S.W.Kim S.-W.Lee Y.C.Moon H.S.Lee S.H.Jung W.T.Kim J.I.Kim K.O.Park J.-J.Chung W.C.Kim J.H.Baik G.H.Oh J.H.Kim S.M.Kim H.S.Yang C.H.Jung J.T.Lim C.H.Song H.J.Kim Y.S.Kim G.H.Kim J.-H.Chung J.-I.Lee J.H.Choi M.H.Choi J.-K.
Ewha Authors
심기남
SCOPUS Author ID
심기남scopus
Issue Date
2018
Journal Title
Gut and Liver
ISSN
1976-2283JCR Link
Citation
Gut and Liver vol. 12, no. 3, pp. 271 - 277
Keywords
Peptic ulcer hemorrhageRebleedingRisk factors
Publisher
Editorial Office of Gut and Liver
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
Background/Aims: Rebleeding is associated with mortality in patients with peptic ulcer bleeding (PUB), and risk stratification is important for the management of these patients. The purpose of our study was to examine the risk factors associated with rebleeding in patients with PUB. Methods: The Korean Peptic Ulcer Bleeding registry is a large prospectively collected database of patients with PUB who were hospitalized between 2014 and 2015 at 28 medical centers in Korea. We examined the basic characteristics and clinical outcomes of patients in this registry. Univariate and multivariate analyses were performed to identify the factors associated with rebleeding. Results: In total, 904 patients with PUB were registered, and 897 patients were analyzed. Rebleeding occurred in 7.1% of the patients (64), and the 30-day mortality was 1.0% (nine patients). According to the multivariate analysis, the risk factors for rebleeding were the presence of co-morbidities, use of multiple drugs, albumin levels, and hematemesis/hematochezia as initial presentations. Conclusions: The presence of co-morbidities, use of multiple drugs, albumin levels, and initial presentations with hematemesis/hematochezia can be indicators of rebleeding in patients with PUB. The wide use of proton pump inhibitors and prompt endoscopic interventions may explain the low incidence of rebleeding and low mortality rates in Korea. © 2018 Editorial Office of Gut and Liver. All rights reserved.
DOI
10.5009/gnl17138
Appears in Collections:
의과대학 > 의학과 > Journal papers
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