View : 23 Download: 0

Increased thrombogenicity in chronic renal failure in a rat model induced by 5/6 ablation/infarction

Title
Increased thrombogenicity in chronic renal failure in a rat model induced by 5/6 ablation/infarction
Authors
Song T.-J.Kwon I.Piao H.Lee J.-E.Han K.-R.Chang Y.Oh H.J.Choi H.-J.Lee K.-Y.Kim Y.-J.Han K.-H.Heo J.H.
Ewha Authors
김용재한기환이지은송태진오형중
SCOPUS Author ID
김용재scopus; 한기환scopus; 이지은scopus; 송태진scopus; 오형중scopus
Issue Date
2018
Journal Title
Yonsei Medical Journal
ISSN
0513-5796JCR Link
Citation
Yonsei Medical Journal vol. 59, no. 6, pp. 754 - 759
Keywords
Chronic renal failureFerric chlorideThromboelastometryThrombosis
Publisher
Yonsei University College of Medicine
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
Purpose: Abnormalities in hemostasis and coagulation have been suggested in chronic renal failure (CRF). In this study, we compared processes of thrombus formation between rats with CRF and those with normal kidney function. Materials and Methods: CRF was induced by 5/6 ablation/infarction of the kidneys in Sprague-Dawley rats, and surviving rats after 4 weeks were used. Ferric chloride (FeCl3)-induced thrombosis in the carotid artery was induced to assess thrombus formation. Whole blood clot formation was evaluated using rotational thromboelastometry (ROTEM). Platelet aggregation was assessed with impedance platelet aggregometry. Results: FeCl3-induced thrombus formation was initiated faster in the CRF group than in the control group (13.2±1.1 sec vs. 17.8±1.0 sec, p=0.027). On histological examination, the maximal diameters of thrombi were larger in the CRF group than in the control group (394.2±201.1 μm vs. 114.0±145.1 μm, p=0.039). In extrinsic pathway ROTEM, the CRF group showed faster clot initiation (clotting time, 59.0±7.3 sec vs. 72.8±5.0 sec, p=0.032) and increased clot growth kinetics (α angle, 84.8±0.2° vs. 82.0±0.6°, p=0.008), compared to the control group. Maximal platelet aggregation rate was higher in the CRF group than in the control group (58.2±0.2% vs. 44.6±1.2%, p=0.006). Conclusion: Our study demonstrated that thrombogenicity is increased in rats with CRF. An activated extrinsic coagulation pathway may play an important role in increasing thrombogenicity in CRF. © Yonsei University College of Medicine 2018.
DOI
10.3349/ymj.2018.59.6.754
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE