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Increased thrombogenicity in chronic renal failure in a rat model induced by 5/6 ablation/infarction
- Title
- Increased thrombogenicity in chronic renal failure in a rat model induced by 5/6 ablation/infarction
- Authors
- Song T.-J.; Kwon I.; Piao H.; Lee J.-E.; Han K.-R.; Chang Y.; Oh H.J.; Choi H.-J.; Lee K.-Y.; Kim Y.-J.; Han K.-H.; Heo J.H.
- Ewha Authors
- 김용재; 한기환; 이지은; 송태진; 오형중
- SCOPUS Author ID
- 김용재; 한기환; 이지은; 송태진; 오형중
- Issue Date
- 2018
- Journal Title
- Yonsei Medical Journal
- ISSN
- 0513-5796
- Citation
- Yonsei Medical Journal vol. 59, no. 6, pp. 754 - 759
- Keywords
- Chronic renal failure; Ferric chloride; Thromboelastometry; Thrombosis
- Publisher
- Yonsei University College of Medicine
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Purpose: Abnormalities in hemostasis and coagulation have been suggested in chronic renal failure (CRF). In this study, we compared processes of thrombus formation between rats with CRF and those with normal kidney function. Materials and Methods: CRF was induced by 5/6 ablation/infarction of the kidneys in Sprague-Dawley rats, and surviving rats after 4 weeks were used. Ferric chloride (FeCl3)-induced thrombosis in the carotid artery was induced to assess thrombus formation. Whole blood clot formation was evaluated using rotational thromboelastometry (ROTEM). Platelet aggregation was assessed with impedance platelet aggregometry. Results: FeCl3-induced thrombus formation was initiated faster in the CRF group than in the control group (13.2±1.1 sec vs. 17.8±1.0 sec, p=0.027). On histological examination, the maximal diameters of thrombi were larger in the CRF group than in the control group (394.2±201.1 μm vs. 114.0±145.1 μm, p=0.039). In extrinsic pathway ROTEM, the CRF group showed faster clot initiation (clotting time, 59.0±7.3 sec vs. 72.8±5.0 sec, p=0.032) and increased clot growth kinetics (α angle, 84.8±0.2° vs. 82.0±0.6°, p=0.008), compared to the control group. Maximal platelet aggregation rate was higher in the CRF group than in the control group (58.2±0.2% vs. 44.6±1.2%, p=0.006). Conclusion: Our study demonstrated that thrombogenicity is increased in rats with CRF. An activated extrinsic coagulation pathway may play an important role in increasing thrombogenicity in CRF. © Yonsei University College of Medicine 2018.
- DOI
- 10.3349/ymj.2018.59.6.754
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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