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The effect of small or diminutive adenomas at baseline colonoscopy on the risk of developing metachronous advanced colorectal neoplasia: KASID multicenter study

Title
The effect of small or diminutive adenomas at baseline colonoscopy on the risk of developing metachronous advanced colorectal neoplasia: KASID multicenter study
Authors
Moon C.M.Jung S.-A.Eun C.S.Park J.J.Seo G.S.Cha J.M.Park S.C.Chun J.Lee H.J.Jung Y.Boo S.-J.Kim J.O.Joo Y.-E.Park D.I.
Ewha Authors
정성애문창모
SCOPUS Author ID
정성애scopus; 문창모scopus
Issue Date
2018
Journal Title
Digestive and Liver Disease
ISSN
1590-8658JCR Link
Citation
Digestive and Liver Disease vol. 50, no. 8, pp. 847 - 852
Keywords
Diminutive adenomaMetachronous colorectal neoplasiaSmall adenomaSurveillance
Publisher
Elsevier B.V.
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Background: The clinical significance of diminutive or small adenomas remains ill defined. Aims: We evaluated the clinical impact of diminutive or small adenomas at baseline on the risk of developing metachronous advanced colorectal neoplasia (CRN). Methods: This multicenter, retrospective cohort study included 2252 patients with 1 or more colorectal adenomas at baseline and subsequent follow-up colonoscopy. Baseline colonoscopy findings were classified into 5 groups: 1 or 2 tubular adenomas (TAs) (<10 mm); 3–10 diminutive TAs (≤5 mm); 3–10 TAs, including 1 or 2 small adenomas (6–10 mm); 3–10 TAs, including 3 or more small adenomas; and advanced adenoma. Results: In multivariate analysis, after adjusting for possible confounding variables (age at baseline, sex, body mass index, smoking habits, family history of colorectal cancer, regular use of aspirin or NSAIDs, and adenoma location), 3–10 TAs including 3 or more small adenomas (hazard ratio [HR] = 2.36, p = 0.034) and advanced adenoma (HR = 2.14, p < 0.001) were independent predictors for the risk of developing metachronous advanced CRN. However, 3–10 diminutive TAs or 3–10 TAs, including 1 or 2 small adenomas, were not associated with this outcome. Conclusions: Multiplicity of diminutive TAs, without advanced lesions, showed no clinical significance for risk of developing metachronous advanced CRN. © 2018 Editrice Gastroenterologica Italiana S.r.l.
DOI
10.1016/j.dld.2018.04.001
Appears in Collections:
의과대학 > 의학과 > Journal papers
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