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Malignant and borderline phyllodes tumors of the breast: a multicenter study of 362 patients (KROG 16-08)

Title
Malignant and borderline phyllodes tumors of the breast: a multicenter study of 362 patients (KROG 16-08)
Authors
Choi, NoorieKim, KyuboShin, Kyung HwanKim, YumiMoon, Hyeong-GonPark, WonChoi, Doo HoKim, Su SsanAhn, Seung DoKim, Tae HyunChun, MisonKim, Yong BaeKim, SuzyChoi, Byung OckKim, Jin Hee
Ewha Authors
김규보
SCOPUS Author ID
김규보scopus
Issue Date
2018
Journal Title
BREAST CANCER RESEARCH AND TREATMENT
ISSN
0167-6806JCR Link

1573-7217JCR Link
Citation
BREAST CANCER RESEARCH AND TREATMENT vol. 171, no. 2, pp. 335 - 344
Keywords
Malignant phyllodes tumorBorderline phyllodes tumorBreast neoplasmAdjuvant therapyRecurrenceRisk factor
Publisher
SPRINGER
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Purpose To identify risk factors for local recurrence (LR) and investigate roles of adjuvant local therapy for malignant and borderline phyllodes tumors of the breast. Methods From 1981 to 2014, 362 patients with malignant (n = 235) and borderline (n = 127) phyllodes tumors were treated by breast-conserving surgery (BCS) or total mastectomy (TM) at 10 centers. Thirty-one patients received adjuvant radiation therapy (RT), and those who received adjuvant chemotherapy were excluded from the study. Results Median follow-up was 5 years. LR developed in 60 (16.6%) patients. Regional recurrence occurred in 2 (0.6%) patients and distant metastasis (DM) developed in 19 (5.2%) patients. Patients receiving BCS (p = 0.025) and those not undergoing adjuvant RT (p = 0.041) showed higher LR rates. For malignant subtypes, local control (LC) rates at 5 years for BCS alone, BCS with adjuvant RT, TM alone, and TM with adjuvant RT were 80.7, 93.3, 92.4, and 100%, respectively (p = 0.033). Multivariate analyses revealed BCS alone, tumor size >= 5 cm, and positive margins as independent risk factors for LR. Margin-positive BCS alone showed poorest LC regardless of tumor size (62.5%, p = 0.007). For margin-negative BCS alone, 5-year LC rates for tumors >= 5 cm versus those < 5 cm were 71.8% versus 89.5% (p = 0.012). For borderline subtypes, only positive margins (p = 0.044) independently increased the risk of LR. DM developed exclusively in malignant subtypes and a prior LR event increased the risk of DM by sixfold (HR 6.2, 95% CI 1.6-16.1, p = 0.001). Conclusions Malignant and borderline phyllodes tumors with positive margins after surgery have high LR rates. After treatment by margin-negative BCS alone, patients with large malignant phyllodes tumors >= 5 cm also have heightened risk of LR. Thus, such patients should be considered for additional local therapy.
DOI
10.1007/s10549-018-4838-3
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의과대학 > 의학과 > Journal papers
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