Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 문병인 | * |
dc.contributor.author | 김희선 | * |
dc.contributor.author | 박진선 | * |
dc.date.accessioned | 2018-12-07T16:30:58Z | - |
dc.date.available | 2018-12-07T16:30:58Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0021-8561 | * |
dc.identifier.other | OAK-20231 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247491 | - |
dc.description.abstract | Morin is a flavonoid isolated from certain fruits and Chinese herbs and is known to possess various medicinal properties. In this study, we investigated the anti-inflammatory effects of morin on lipopolysaccharide (LPS)-induced microglial activation, both in vitro and in vivo. We found that morin inhibited inducible nitric oxide synthase (iNOS) and pro-inflammatory cytokines in LPS-stimulated BV2 microglial cells. Furthermore, morin suppressed the microglial activation and cytokine expression in the brains of LPS-stimulated mice. Subsequent mechanistic studies revealed that morin inhibited the action of LPSactivated mitogen- Activated protein kinases (MAPKs), protein kinase B (Akt) phosphorylation, nuclear factor-κB (NF-κB), and activating protein-1 (AP-1). Further, the phosphorylation and DNA binding activity of cAMP responsive element binding protein (CREB) was enhanced by morin. Moreover, morin suppressed the LPS-induced expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits, while it increased heme oxygenase-1 (HO-1) expression and nuclear factor erythroid 2- related factor 2 (Nrf2) activation. Therefore, our data suggest that morin exerts anti-inflammatory effects in LPS-stimulated microglia by downregulating MAPK and phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways while upregulating protein kinase A (PKA)/CREB and Nrf2/HO-1 signaling pathways. © 2016 American Chemical Society. | * |
dc.description.sponsorship | Ministry of Science ICT and Future Planning | * |
dc.language | English | * |
dc.publisher | American Chemical Society | * |
dc.subject | Anti-inflammation | * |
dc.subject | Microglia | * |
dc.subject | Molecular mechanisms | * |
dc.subject | Morin | * |
dc.subject | Neuroinflammation | * |
dc.title | Suppression of lipopolysaccharide-induced neuroinflammation by morin via MAPK, PI3K/Akt, and PKA/HO-1 signaling pathway modulation | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 65 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 373 | * |
dc.relation.lastpage | 382 | * |
dc.relation.journaltitle | Journal of Agricultural and Food Chemistry | * |
dc.identifier.doi | 10.1021/acs.jafc.6b05147 | * |
dc.identifier.wosid | WOS:000392458900015 | * |
dc.identifier.scopusid | 2-s2.0-85020411140 | * |
dc.author.google | Jung J.-S. | * |
dc.author.google | Choi M.-J. | * |
dc.author.google | Lee Y.Y. | * |
dc.author.google | Moon B.-I. | * |
dc.author.google | Park J.-S. | * |
dc.author.google | Kim H.-S. | * |
dc.contributor.scopusid | 문병인(7101878644;56119062300) | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.contributor.scopusid | 박진선(54914743600) | * |
dc.date.modifydate | 20240215165648 | * |