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Efficacy of levofloxacin-based third-line therapy for the eradication of helicobacter pylori in peptic ulcer disease
- Title
- Efficacy of levofloxacin-based third-line therapy for the eradication of helicobacter pylori in peptic ulcer disease
- Authors
- Lim J.H.; Kim S.G.; Song J.H.; Hwang J.J.; Lee D.H.; Han J.P.; Hong S.J.; Kim J.H.; Jeon S.W.; Kim G.H.; Shim K.-N.; Shin W.G.; Kim T.H.; Kim S.M.; Chung I.-K.; Kim H.-S.; Kim H.U.; Lee J.; Kim J.G.
- Ewha Authors
- 심기남
- SCOPUS Author ID
- 심기남
- Issue Date
- 2017
- Journal Title
- Gut and Liver
- ISSN
- 1976-2283
- Citation
- Gut and Liver vol. 11, no. 2, pp. 226 - 231
- Keywords
- Helicobacter pylori; Levofloxacin; Third-line eradication
- Publisher
- Joe Bok Chung
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Background/Aims: The resistance rate of Helicobacter pylori is gradually increasing. We aimed to evaluate the efficacy of levofloxacin-based third-line H. pylori eradication in peptic ulcer disease. Methods: Between 2002 and 2014, 110 patients in 14 medical centers received levofloxacin-based third-line H. pylori eradication therapy for peptic ulcer disease. Of these, 88 were included in the study; 21 were excluded because of lack of follow-up and one was excluded for poor compliance. Their eradication rates, treatment regimens and durations, and types of peptic ulcers were analyzed. Results: The overall eradiation rate was 71.6%. The adherence rate was 80.0%. All except one received a protonpump inhibitor, amoxicillin, and levofloxacin. One received a proton-pump inhibitor, amoxicillin, levofloxacin, and clarithromycin, and the eradication was successful. Thirty-one were administered the therapy for 7 days, 25 for 10 days, and 32 for 14 days. No significant differences were observed in the eradication rates between the three groups (7-days, 80.6% vs 10-days, 64.0% vs 14-days, 68.8%, p=0.353). Additionally, no differences were found in the eradiation rates according to the type of peptic ulcer (gastric ulcer, 73.2% vs duodenal/ gastroduodenal ulcer, 68.8%, p=0.655). Conclusions: Levofloxacin-based third-line H. pylori eradication showed efficacy similar to that of previously reported first/second-line therapies.
- DOI
- 10.5009/gnl16099
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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