Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이진화 | * |
dc.date.accessioned | 2018-12-07T16:30:44Z | - |
dc.date.available | 2018-12-07T16:30:44Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1176-9106 | * |
dc.identifier.other | OAK-20648 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247412 | - |
dc.description.abstract | Purpose: The purpose of this study was to identify subtypes in patients with mild-to-moderate airflow limitation and to appreciate their clinical and socioeconomic implications. Methods: Subjects who were aged ≥20 years and had forced expiratory volume in 1 second (FEV1) ≥60% predicted and FEV1/forced vital capacity <0.7 were selected from the fourth Korea National Health and Nutrition Examination Survey (KNHANES) in 2007–2012. The data were merged to the National Health Insurance reimbursement database during the same period. k-Means clustering was performed to explore subtypes. For clustering analysis, six key input variables – age, body mass index (BMI), FEV1% predicted, the presence or absence of self-reported wheezing, smoking status, and pack-years of smoking – were selected. Results: Among a total of 2,140 subjects, five groups were identified through k-means clustering, namely putative “near-normal (n=232),” “asthmatic (n=392),” “chronic obstructive pulmonary disease (COPD) (n=37),” “asthmatic-overlap (n=893),” and “COPD-overlap (n=586)” subtypes. Near-normal group showed the oldest mean age (72±7 years) and highest FEV1 (102%±8% predicted), and asthmatic group was the youngest (46±9 years). COPD and COPD-overlap groups were male predominant and all current or ex-smokers. While asthmatic group had the lowest prescription rate despite the highest proportion of self-reported wheezing, COPD, asthmatic-overlap, and COPD-overlap groups showed high prescription rate of respiratory medicine. Although COPD group formed only 1.7% of total subjects, they showed the highest mean medical cost and health care utilization, comprising 5.3% of the total medical cost. When calculating a ratio of total medical expense to household income, the mean ratio was highest in the COPD group. Conclusion: Clinical and epidemiological heterogeneities of subjects with mild-to-moderate airflow limitation and a different level of health care utilization by each subtype are shown. Identification of a subtype with high health care demand could be a priority for effective utilization of limited resources. © 2017 Lee et al. | * |
dc.description.sponsorship | Ministry of Science, ICT and Future Planning | * |
dc.language | English | * |
dc.publisher | Dove Medical Press Ltd. | * |
dc.subject | Asthma | * |
dc.subject | Cluster | * |
dc.subject | COPD | * |
dc.subject | Health care utilization | * |
dc.subject | Overlap | * |
dc.subject | Phenotype | * |
dc.title | Identification of subtypes in subjects with mild-to-moderate airflow limitation and its clinical and socioeconomic implications | * |
dc.type | Article | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1135 | * |
dc.relation.lastpage | 1144 | * |
dc.relation.journaltitle | International Journal of COPD | * |
dc.identifier.doi | 10.2147/COPD.S130140 | * |
dc.identifier.wosid | WOS:000399291200001 | * |
dc.identifier.scopusid | 2-s2.0-85018490586 | * |
dc.author.google | Lee J.H. | * |
dc.author.google | Rhee C.K. | * |
dc.author.google | Kim K. | * |
dc.author.google | Kim J.-A. | * |
dc.author.google | Kim S.H. | * |
dc.author.google | Yoo K.H. | * |
dc.author.google | Kim W.J. | * |
dc.author.google | Park Y.B. | * |
dc.author.google | Park H.Y. | * |
dc.author.google | Jung K.-S. | * |
dc.contributor.scopusid | 이진화(56646645800;58376333800) | * |
dc.date.modifydate | 20240419140935 | * |