Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유영민 | * |
dc.contributor.author | 전상범 | * |
dc.date.accessioned | 2018-12-07T16:30:43Z | - |
dc.date.available | 2018-12-07T16:30:43Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0020-1669 | * |
dc.identifier.other | OAK-20657 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247404 | - |
dc.description.abstract | The study of the zinc biology requires molecular probes with proper zinc affinity. We developed a low-affinity zinc probe (HBO-ACR) based on an azacrown ether (ACR) and an 2-(2-hydroxyphenyl)benzoxazole (HBO) fluorophore. This probe design imposed positive charge in the vicinity of a zinc coordination center, which enabled fluorescence turn-on responses to high levels of zinc without being affected by the pH and the presence of other transition-metal ions. Steady-state and transient photophysical investigations suggested that such a high tolerance benefits from orchestrated actions of proton-induced nonradiative and zinc-induced radiative control. The zinc bioimaging utility of HBO-ACR has been fully demonstrated with the use of human pancreas epidermoid carcinoma, PANC-1 cells, and rodent hippocampal neurons from cultures and acute brain slices. The results obtained through our studies established the validity of incorporating positively charged ionophores for the creation of low-affinity probes for the visualization of biometals. © 2017 American Chemical Society. | * |
dc.description.sponsorship | National Research Foundation of Korea | * |
dc.language | English | * |
dc.publisher | American Chemical Society | * |
dc.title | Low-Affinity Zinc Sensor Showing Fluorescence Responses with Minimal Artifacts | * |
dc.type | Article | * |
dc.relation.issue | 8 | * |
dc.relation.volume | 56 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 4332 | * |
dc.relation.lastpage | 4346 | * |
dc.relation.journaltitle | Inorganic Chemistry | * |
dc.identifier.doi | 10.1021/acs.inorgchem.6b02786 | * |
dc.identifier.wosid | WOS:000399625600014 | * |
dc.identifier.scopusid | 2-s2.0-85018471434 | * |
dc.author.google | Yan X. | * |
dc.author.google | Kim J.J. | * |
dc.author.google | Jeong H.S. | * |
dc.author.google | Moon Y.K. | * |
dc.author.google | Cho Y.K. | * |
dc.author.google | Ahn S. | * |
dc.author.google | Jun S.B. | * |
dc.author.google | Kim H. | * |
dc.author.google | You Y. | * |
dc.contributor.scopusid | 유영민(24759463600) | * |
dc.contributor.scopusid | 전상범(15843339100) | * |
dc.date.modifydate | 20240322125603 | * |