Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정지향 | * |
dc.date.accessioned | 2018-12-07T16:30:31Z | - |
dc.date.available | 2018-12-07T16:30:31Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1738-6586 | * |
dc.identifier.other | OAK-21022 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247341 | - |
dc.description.abstract | Background and Purpose Only a few studies have investigated the relationship between different subtypes and disease progression or prognosis in patients with behavioral variant frontotemporal dementia (bvFTD). Since a localized injury often produces more focal signs than a diffuse injury, we hypothesized that the clinical characteristics differ between patients with bvFTD who show diffuse frontal lobe atrophy (D-type) on axial magnetic resonance imaging (MRI) scans versus those with focal or circumscribed frontal lobe atrophy (F-type). Methods In total, 94 MRI scans (74 scans from bvFTD and 20 scans from age-matched normal controls) were classified into 35 D- and 39 F-type bvFTD cases based on an axial MRI visual rating scale. We compared baseline clinical characteristics, progression in motor and cognitive symptoms, and survival times between D- and F-types. Survival analyses were performed for 62 of the 74 patients. Results While D-type performed better on neuropsychological tests than F-type at baseline, D-type had higher baseline scores on the Unified Parkinson’s Disease Rating Scale (UPDRS) Part III. Evaluations of motor progression showed that the disease duration with motor symptoms was shorter in D-type than F-type. Moreover, the survival time was shorter in D-type (6.9 years) than F-type (9.4 years). Cox regression analyses revealed that a high UPDRS Part III score at baseline contributed to an increased risk of mortality, regardless of the pattern of atrophy. Conclusions The prognosis is worse for D-type than for those with F-type. Shorter survival in D-type may be associated with the earlier appearance of motor symptoms. © 2017 Korean Neurological Association. | * |
dc.language | English | * |
dc.publisher | Korean Neurological Association | * |
dc.subject | Frontotemporal dementia | * |
dc.subject | Frontotemporal lobar degeneration | * |
dc.subject | Magnetic resonance imaging | * |
dc.subject | Prognosis | * |
dc.title | Prognosis of patients with behavioral variant frontotemporal dementia who have focal versus diffuse frontal atrophy | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 13 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 234 | * |
dc.relation.lastpage | 242 | * |
dc.relation.journaltitle | Journal of Clinical Neurology (Korea) | * |
dc.identifier.doi | 10.3988/jcn.2017.13.3.234 | * |
dc.identifier.wosid | WOS:000405538000003 | * |
dc.identifier.scopusid | 2-s2.0-85026442599 | * |
dc.author.google | Lee J.S. | * |
dc.author.google | Jung N.-Y. | * |
dc.author.google | Jang Y.K. | * |
dc.author.google | Kim H.J. | * |
dc.author.google | Seo S.W. | * |
dc.author.google | Lee J. | * |
dc.author.google | Kim Y.J. | * |
dc.author.google | Lee J.-H. | * |
dc.author.google | Kim B.C. | * |
dc.author.google | Park K.-W. | * |
dc.author.google | Yoon S.J. | * |
dc.author.google | Jeong J.H. | * |
dc.author.google | Kim S.Y. | * |
dc.author.google | Kim S.H. | * |
dc.author.google | Kim E.-J. | * |
dc.author.google | Park K.-C. | * |
dc.author.google | Knopman D.S. | * |
dc.author.google | Na D.L. | * |
dc.contributor.scopusid | 정지향(7402045750;57192068764) | * |
dc.date.modifydate | 20240123101416 | * |