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Gut microbiota and physiologic bowel 18F-FDG uptake

Title
Gut microbiota and physiologic bowel 18F-FDG uptake
Authors
Kang J.Y.Kim H.-N.Chang Y.Yun Y.Ryu S.Shin H.Kim H.-L.
Ewha Authors
김형래
SCOPUS Author ID
김형래scopus
Issue Date
2017
Journal Title
EJNMMI Research
ISSN
2191-219XJCR Link
Citation
EJNMMI Research vol. 7
Keywords
18F-FDG PETGut microbiotaIntestinalPermeabilityPhysiologic
Publisher
Springer Verlag
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Background: We investigated the association between physiologic bowel FDG uptake and gut microbiota. FDG uptake in the normal large and small intestine is widely variable both in distribution and intensity. The etiology of physiologic bowel 18F-FDG activity remains unknown. Results: We included 63 healthy male subjects. After overnight fasting, blood samples and 18F-FDG PET/CT scans were taken. Fecal samples were collected, and gut microbiota were analyzed by 16S rRNA gene-pyrosequencing. The physiologic bowel FDG uptake was classified into three groups by visual assessment and measured using the maximum and mean standardized uptake value. We used the total bowel to liver uptake ratio (TBRmax and TBRmean). There was no significant difference in age, BMI, or lipid profiles between groups. To identify specific microbial taxa associated with the bowel FDG uptake while accounting for age and BMI, we performed a generalized linear model. At the genus level, the group with focal or intense FDG uptake in the intestine was associated with low abundance of unclassified Clostridiales. The group with intestinal FDG uptake lower than the liver was associated with high abundance of Klebsiella. TBRmax and TBRmean were negatively associated with abundance of unclassified Enterobacteriaceae. Conclusion: We cautiously speculate that physiologic bowel FDG activity might be caused by an increase in intestinal permeability and may reflect an impaired barrier function in the intestine. © 2017, The Author(s).
DOI
10.1186/s13550-017-0318-8
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의과대학 > 의학과 > Journal papers
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