Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희선 | * |
dc.contributor.author | 김한수 | * |
dc.date.accessioned | 2018-12-07T16:30:18Z | - |
dc.date.available | 2018-12-07T16:30:18Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1976-9148 | * |
dc.identifier.other | OAK-21579 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247266 | - |
dc.description.abstract | Galangin (3,5,7-trihydroxyflavone) is a polyphenolic compound abundant in honey and medicinal herbs, such as Alpinia officinarum. In this study, we investigated the anti-inflammatory effects of galangin under in vitro and in vivo neuroinflammatory conditions caused by polyinosinic-polycytidylic acid (poly(I:C)), a viral mimic dsRNA analog. Galangin suppressed the production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in poly(I:C)-stimulated BV2 microglia. On the other hand, galangin enhanced anti-inflammatory interleukin (IL)-10 production. Galangin also suppressed the expression of pro-inflammatory markers in poly(I:C)-injected mouse brains. Further mechanistic studies showed that galangin inhibited poly(I:C)-induced nuclear factor (NF)-κB activity and phosphorylation of Akt without affecting MAP kinases. Interestingly, galangin increased the expression and transcriptional activity of peroxisome proliferator-activated receptor (PPAR)-γ, known to play an anti-inflammatory role. To investigate whether PPAR-γ is involved in the anti-inflammatory function of galangin, BV2 cells were pre-treated with PPAR-γ antagonist before treatment of galangin. We found that PPAR-γ antagonist significantly blocked galangin-mediated upregulation of IL-10 and attenuated the inhibition of tumor necrosis factor (TNF)-α and IL-6 in poly(I:C)-stimulated microglia. In conclusion, our data suggest that PI3K/Akt, NF-κB, and PPAR-γ play a pivotal role in mediating the anti-inflammatory effects of galangin in poly(I:C)-stimulated microglia. © 2017 The Korean Society of Applied Pharmacology. | * |
dc.description.sponsorship | Ministry of Science, ICT and Future Planning | * |
dc.language | English | * |
dc.publisher | Korean Society of Applied Pharmacology | * |
dc.subject | Galangin | * |
dc.subject | Microglia | * |
dc.subject | NF-κB | * |
dc.subject | PI3K/Akt | * |
dc.subject | Poly(I:C) | * |
dc.subject | PPAR-γ signaling | * |
dc.title | Galangin suppresses pro-inflammatory gene expression in polyinosinic-polycytidylic acid-stimulated microglial cells | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 25 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 641 | * |
dc.relation.lastpage | 647 | * |
dc.relation.journaltitle | Biomolecules and Therapeutics | * |
dc.identifier.doi | 10.4062/biomolther.2017.173 | * |
dc.identifier.wosid | WOS:000415274600011 | * |
dc.identifier.scopusid | 2-s2.0-85033606834 | * |
dc.author.google | Choi M.-J. | * |
dc.author.google | Park J.-S. | * |
dc.author.google | Park J.-E. | * |
dc.author.google | Kim H.S. | * |
dc.author.google | Kim H.-S. | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.contributor.scopusid | 김한수(56509934900) | * |
dc.date.modifydate | 20240422114059 | * |