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Salvage radiotherapy for locoregionally recurrent extrahepatic bile duct cancer after radical surgery

Title
Salvage radiotherapy for locoregionally recurrent extrahepatic bile duct cancer after radical surgery
Authors
Kim E.Kim Y.-J.Kim K.Song C.Kim J.-S.Oh D.-Y.Nam E.M.Chie E.K.
Ewha Authors
남은미김규보
SCOPUS Author ID
남은미scopus; 김규보scopus
Issue Date
2017
Journal Title
British Journal of Radiology
ISSN
0007-1285JCR Link
Citation
British Journal of Radiology vol. 90, no. 1080
Publisher
British Institute of Radiology
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Objective: This study evaluated the outcome of salvage radiotherapy for locoregionally recurrent extrahepatic bile duct cancer. Methods: We performed a retrospective review of 23 extrahepatic bile duct cancer patients who underwent radiotherapy with or without concomitant chemotherapy for isolated locoregional recurrence after radical surgery between August 2001 and September 2013. The median disease-free interval was 11.8 months. Salvage radiotherapy was delivered to the recurrent tumour with or without initial operation bed up to a median dose of 54 Gy (range, 45-60). 18 patients received concomitant chemotherapy. Results: The median follow-up period was 14.2 months for all patients, and 48.8 months for survivors. The median overall survival and progression-free survival (PFS) were 18.4 (range, 4.4-114.6) and 15.5 months (range, 1.6-114.6), respectively. On multivariate analysis, the use of concomitant chemotherapy was a favourable prognostic factor for PFS (p = 0.027), and prolonged disease-free interval (≥1 year) was associated with a significantly poor overall survival (p = 0.047). Grade 3 or higher toxicities did not occur in follow-up period. Conclusion: Salvage radiotherapy showed promising survival outcomes in locoregional recurrence of extrahe-patic bile duct cancer. Our results indicated that concomitant chemotherapy was associated with improved PFS. Concurrent chemoradiotherapy can be a viable salvage treatment option in selected patients. Advances in knowledge: Locoregional recurrence is the most common pattern of failure after radical resection in extrahepatic bile duct cancer. In this study, salvage radiotherapy showed favourable survival outcomes without severe complications in locoregionally recurrent extra-hepatic bile duct cancer patients. © 2017 The Authors. Published by the British Institute of Radiology.
DOI
10.1259/bjr.20170308
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의과대학 > 의학과 > Journal papers
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