Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이진화 | * |
dc.date.accessioned | 2018-12-07T16:30:14Z | - |
dc.date.available | 2018-12-07T16:30:14Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1465-993X | * |
dc.identifier.other | OAK-21827 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247245 | - |
dc.description.abstract | BACKGROUND: The effects of corticosteroid-based therapy in patients with idiopathic nonspecific interstitial pneumonia (iNSIP), and factors affecting treatment outcome, are not fully understood. We aimed to investigate the long-term treatment response and factors affecting the treatment outcome in iNSIP patients from a multi-center study in Korea.METHODS: The Korean interstitial lung disease (ILD) Study Group surveyed ILD patients from 2003 to 2007. Patients were divided into two groups to compare the treatment response: response group (forced vital capacity (FVC) improves ≥10% after 1 year) and non-response group (FVC <10%). Factors affecting treatment response were evaluated by multivariate logistic regression analysis.RESULTS: A total of 261 patients with iNSIP were enrolled, and 95 patients were followed-up for more than 1 year. Corticosteroid treatment was performed in 86 patients. The treatment group showed a significant improvement in lung function after 1-year: FVC, 10.0%; forced expiratory volume (FEV1), 9.8%; diffusing capacity of the lung for carbon monoxide (DLco), 8.4% (p < 0.001). Sero-negative anti-nuclear antibody (ANA) was significantly related with lung function improvement. Sero-positivity ANA was significantly lower in the response group (p = 0.013), compared to that in the non-response group. A shorter duration of respiratory symptoms at diagnosis was significantly associated with a good response to treatment (p = 0.018).CONCLUSION: Treatment with corticosteroids and/or immunosuppressants improved lung function in iNSIP patients, which was more pronounced in sero-negative ANA and shorter symptom duration patients. These findings suggest that early treatment should be considered in iNSIP patients, even in an early disease stage. | * |
dc.language | English | * |
dc.subject | Non-specific interstitial pneumonia | * |
dc.subject | Pulmonary lung function | * |
dc.subject | Treatment | * |
dc.title | Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 18 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 204 | * |
dc.relation.journaltitle | Respiratory research | * |
dc.identifier.doi | 10.1186/s12931-017-0686-7 | * |
dc.identifier.wosid | WOS:000417509400002 | * |
dc.identifier.scopusid | 2-s2.0-85050662015 | * |
dc.author.google | Lee S.H. | * |
dc.author.google | Park M.S. | * |
dc.author.google | Kim S.Y. | * |
dc.author.google | Kim D.S. | * |
dc.author.google | Kim Y.W. | * |
dc.author.google | Chung M.P. | * |
dc.author.google | Uh S.T. | * |
dc.author.google | Park C.S. | * |
dc.author.google | Park S.W. | * |
dc.author.google | Jeong S.H. | * |
dc.author.google | Park Y.B. | * |
dc.author.google | Lee H.L. | * |
dc.author.google | Shin J.W. | * |
dc.author.google | Lee E.J. | * |
dc.author.google | Lee J.H. | * |
dc.author.google | Jegal Y. | * |
dc.author.google | Lee H.K. | * |
dc.author.google | Kim Y.H. | * |
dc.author.google | Song J.W. | * |
dc.author.google | Park J.S. | * |
dc.contributor.scopusid | 이진화(56646645800;58376333800) | * |
dc.date.modifydate | 20240419140935 | * |