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The effect of probiotics, antibiotics, and antipyretic analgesics on gut microbiota modification
- The effect of probiotics, antibiotics, and antipyretic analgesics on gut microbiota modification
- Yun Y.; Kim H.-N.; Kim S.E.; Chang Y.; Ryu S.; Shin H.; Woo S.-Y.; Kim H.-L.
- Ewha Authors
- 김형래; 우소연; 김한나; 윤여준; 김송이
- SCOPUS Author ID
- 김형래; 우소연; 김한나; 윤여준
- Issue Date
- Journal Title
- Journal of Bacteriology and Virology
- Journal of Bacteriology and Virology vol. 47, no. 1, pp. 64 - 74
- Antibiotics; Antipyretic analgesics; Gut microbiota; Probiotics
- The Korean Society for Mocrobiology / The Korean Society of Virology
- SCOPUS; KCI
- Document Type
- Human gut microbial community is playing a critical role in human health and associated with different human disease. In parallel, probiotics, antibiotics, and antipyretic analgesics (AAs) were developed to improve human health or cure human diseases. We therefore examined how probiotics, antibiotics, and AAs influence to the gut microbiota. Three independent case/control studies were designed from the cross-sectional cohort data of 1,463 healthy Koreans. The composition of the gut microbiota in each case and control group was determined via 16S ribosomal RNA Illumina next-generation sequencing. The correlation between microbial taxa and the consumption of each drug was tested using zero-inflated Gaussian mixture models, with covariate adjustment of age, sex, and body mass index (BMI). Probiotics, antibiotics, and AAs consumption yielded the significant differences in the gut microbiota, represented the lower abundance of Megasphaera in probiotics, the higher abundance of Fusobacteria in antibiotics, and the higher abundance of Butyrivibrio and Verrucomicrobia in AAs, compared to each control group. The reduction of Erysipelotrichaceae family was common in three drugs consumption. © 2017, Chonnam National University Medical School. All rights reserved.
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