Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.date.accessioned | 2018-11-23T16:30:19Z | - |
dc.date.available | 2018-11-23T16:30:19Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1976-9148 | * |
dc.identifier.other | OAK-23701 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247076 | - |
dc.description.abstract | Benzylideneacetophenone derivative (1E)-1-(4-hydroxy-3-methoxyphenyl) hept-1-en-3-one (JC3) elicited cytotoxic effects on MDA-MB 231 human breast cancer cells-radiation resistant cells (MDA-MB 231-RR), in a dose-dependent manner, with an IC50 value of 6 μM JC3. JC3-mediated apoptosis was confirmed by increase in sub-G1 cell population. JC3 disrupted the mitochondrial membrane potential, and reduced expression of anti-apoptotic B cell lymphoma-2 protein, whereas it increased expression of pro-apoptotic Bcl-2-associated X protein, leading to the cleavage of caspase-9, caspase-3 and poly (ADP-ribose) polymerase. In addition, JC3 activated mitogen-activated protein kinases, and specific inhibitors of these kinases abrogated the JC3-induced increase in apoptotic bodies. JC3 increased the level of intracellular reactive oxygen species and enhanced oxidative macromolecular damage via lipid peroxidation, protein carbonylation, and DNA strand breakage. Considering these findings, JC3 is an effective therapy against radiation-resistant human breast cancer cells. © 2017 The Korean Society of Applied Pharmacology. | * |
dc.description.sponsorship | Ministry of Education, Science and Technology | * |
dc.language | English | * |
dc.publisher | Korean Society of Applied Pharmacology | * |
dc.subject | Apoptosis | * |
dc.subject | Benzylideneacetophenone derivative | * |
dc.subject | Radiation resistance | * |
dc.subject | Reactive oxygen species | * |
dc.title | A benzylideneacetophenone derivative induces apoptosis of radiation-resistant human breast cancer cells via oxidative stress | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 25 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 404 | * |
dc.relation.lastpage | 410 | * |
dc.relation.journaltitle | Biomolecules and Therapeutics | * |
dc.identifier.doi | 10.4062/biomolther.2017.010 | * |
dc.identifier.scopusid | 2-s2.0-85023600396 | * |
dc.author.google | Park J.E. | * |
dc.author.google | Piao M.J. | * |
dc.author.google | Kang K.A. | * |
dc.author.google | Shilnikova K. | * |
dc.author.google | Hyun Y.J. | * |
dc.author.google | Oh S.K. | * |
dc.author.google | Jeong Y.J. | * |
dc.author.google | Chae S. | * |
dc.author.google | Hyun J.W. | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.date.modifydate | 20240118133340 | * |