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Implications of circadian rhythm in dopamine and mood regulation

Title
Implications of circadian rhythm in dopamine and mood regulation
Authors
Kim J.Jang S.Choe H.K.Chung S.Son G.H.Kim K.
Ewha Authors
정수영
SCOPUS Author ID
정수영scopus
Issue Date
2017
Journal Title
Molecules and Cells
ISSN
1016-8478JCR Link
Citation
Molecules and Cells vol. 40, no. 7, pp. 450 - 456
Keywords
Circadian rhythm; Dopaminergic system; Mood disorder; Parkinson’s disease; REV-ERBα
Publisher
Korean Society for Molecular and Cellular Biology
Indexed
SCI; SCIE; SCOPUS; KCI scopus
Document Type
Review
Abstract
Mammalian physiology and behavior are regulated by an internal time-keeping system, referred to as circadian rhythm. The circadian timing system has a hierarchical organization composed of the master clock in the suprachiasmatic nucleus (SCN) and local clocks in extra-SCN brain regions and peripheral organs. The circadian clock molecular mechanism involves a network of transcription-translation feedback loops. In addition to the clinical association between circadian rhythm disruption and mood disorders, recent studies have suggested a molecular link between mood regulation and circadian rhythm. Specifically, genetic deletion of the circadian nuclear receptor Rev-erbα induces mania-like behavior caused by increased midbrain dopaminergic (DAergic) tone at dusk. The association between circadian rhythm and emotion- related behaviors can be applied to pathological conditions, including neurodegenerative diseases. In Parkinson’s disease (PD), DAergic neurons in the substantia nigra pars compacta progressively degenerate leading to motor dysfunction. Patients with PD also exhibit non-motor symptoms, including sleep disorder and neuropsychiatric disorders. Thus, it is important to understand the mechanisms that link the molecular circadian clock and brain machinery in the regulation of emotional behaviors and related midbrain DAergic neuronal circuits in healthy and pathological states. This review summarizes the current literature regarding the association between circadian rhythm and mood regulation from a chronobiological perspective, and may provide insight into therapeutic approaches to target psychiatric symptoms in neurodegenerative diseases involving circadian rhythm dysfunction. © The Korean Society for Molecular and Cellular Biology. All rights reserved.
DOI
10.14348/molcells.2017.0065
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스크랜튼대학 > 융합학부 > Journal papers
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