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Use of autoantibodies against tumor-associated antigens as serum biomarkers for primary screening of cervical cancer

Title
Use of autoantibodies against tumor-associated antigens as serum biomarkers for primary screening of cervical cancer
Authors
Jin, YingjiKim, Seung CheolKim, Hyoung JinJu, WoongKim, Yun HwanKim, Hong-Jin
Ewha Authors
김승철주웅김윤환
SCOPUS Author ID
김승철scopus; 주웅scopus; 김윤환scopus
Issue Date
2017
Journal Title
ONCOTARGET
ISSN
1949-2553JCR Link
Citation
ONCOTARGET vol. 8, no. 62, pp. 105425 - 105439
Keywords
cervical cancerautoantibodytumor associated antigenenzyme-linked immunosorbent assaycervical intraepithelial neoplasia
Publisher
IMPACT JOURNALS LLC
Indexed
SCOPUS WOS scopus
Document Type
Article
Abstract
Serum autoantibodies against tumor-associated antigens (TAAs) have received much attention as potential biomarkers for early detection of cancers, since they can be detected in the early stages of cancers. Autoantibodies against Cancer Antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA), Cancer Antigen 19-9 (CA19-9), c-Myc, p53, heat shock protein (Hsp) 27 and Hsp70 have been suggested as potential markers for detecting several types of cancer. In the present study, the seven types of antibody listed above were evaluated for detecting cervical lesions. Enzymelinked immunosorbent assays (ELISAs) were used to measure IgG levels of the autoantibodies in women with normal cytology, cervical intraepithelial neoplasia (CIN) I, CIN II, CIN III and cervical cancer. The increases of anti-CA15-3 and anti-CEA IgG in cervical cancer were more pronounced than the increases of the other markers, and the level of anti-CA19-9 IgG in CIN III stage was higher than in normal CIN I, CIN II or cervical cancer. A combination of ELISAs detecting anti-CA15-3, anti-CEA and anti-CA19-9 IgGs was found to reliably discriminate CINs from normal and to strongly differentiate cancer from normal (90.3% of sensitivity and 82.1% of specificity). We suggest that the combination of three ELISA may be useful for detecting cervical lesions.
DOI
10.18632/oncotarget.22231
Appears in Collections:
의과대학 > 의학과 > Journal papers
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